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Table 3 Associations between CYP1A2, UGT1A4, and ABCB1 genotypes and autonomic nervous system activity

From: The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine

CYP1A2

 

rs2069514

rs762551

G/G

G/A, A/A

P

C/C

C/A, A/A

P

56

35

 

21

70

 

lnLF (ms2)

4.40 ± 1.12

4.17 ± 1.11

0.337

4.84 ± 0.84

4.16 ± 1.15

0.013

lnHF (ms2)

3.86 ± 1.22

3.72 ± 1.05

0.597

4.15 ± 1.45

3.70 ± 1.03

0.119

lnTP (ms2)

4.98 ± 1.04

4.84 ± 0.92

0.511

5.37 ± 0.96

4.80 ± 0.97

0.020

UGT1A4

 

rs2011425

 

T/T

G/T, G/G

P

73

18

 

lnLF (ms2)

4.14 ± 1.07

5.06 ± 1.04

0.001 a

lnHF (ms2)

3.59 ± 0.93

3.86 ± 1.20

0.378

lnTP (ms2)

4.82 ± 0.98

5.35 ± 0.95

0.042

ABCB1

 

rs1045642

rs1128503

C/C

C/T, T/T

P

T/T

C/T, C/C

P

24

67

 

43

48

 

lnLF (ms2)

4.27 ± 1.19

4.34 ± 1.10

0.803

4.26 ± 1.07

4.37 ± 1.17

0.649

lnHF (ms2)

3.97 ± 1.12

3.75 ± 1.16

0.423

3.69 ± 1.19

3.91 ± 1.12

0.370

lnTP (ms2)

4.96 ± 1.03

4.92 ± 0.98

0.845

4,85 ± 1.01

5.00 ± 0.98

0.486

ABCB1

 

rs2032582

rs2235048

G/G

G/A•T, A•T/A•T

P

T/T

C/C, C/T

P

16

75

 

24

67

 

lnLF (ms2)

4.11 ± 1.07

4.36 ± 1.13

0.419

4.27 ± 1.19

4.34 ± 1.10

0.803

lnHF (ms2)

3.80 ± 1.44

3.81 ± 1.09

0.977

3.97 ± 1.12

3.75 ± 1.16

0.423

lnTP (ms2)

4.83 ± 1.06

4.95 ± 0.98

0.665

4.96 ± 1.03

4.92 ± 0.98

0.845

  1. Data are presented as mean ± standard deviation values
  2. ln natural log-transformed, HF High frequency, LF Low frequency, TP Total power
  3. a Significant difference (p < 0.007; Student’s t-test)