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Table 1 A review table of the existing structural work in bulimia nervosa

From: Altered regional gray matter volume in Chinese female patients with bulimia nervosa

Authors&Journal

Participants

Mean Age (SD)

Method

Findings

Regional Differences

Total Volume Difference

Schäfer et.al (2010) [4] Neuroimage. 2010;50 (2):639–43

BN(n = 14) BED(n = 17) HC(n = 19)

BN:23.1 (3.8) BED:26.4 (6.4) HC:22.3 (2.6)

VBM

Increased GMV of the medial OFC and the ventral striatum in BN (BN > HC).

Not assessed

Frank et.al(2013) [5] Am J Psychiatry. 2013;170 (10):1152–60

AN(n = 19) Recovered AN(n = 24)BN(n = 20) HC(n = 24)

AN:23.1 (5.8) Recovered AN:30.3 (8.1) BN:25.2 (5.3) HC:27.4 (6.3)

VBM

Increased GMV in the Left orbitofrontal cortex and anterior ventral insula (BN > HC);reduced GMV in the bilateral dorsal caudate and dorsal putamen in BN (BN < HC).

There was no significant difference between BN and HC in GMV, WMV and TIV(P > 0.05).

Coutinho et.al(2015) [7] Int J Eat Disord. 2015;48 (2):206–14

BN(n = 21) HC(n = 20)

BN:31.57 (8.27) HC:30.90 (8.79)

VBM

Reduced volume of caudate nucleus in BN (BN < HC).

There was no significant difference between BN and HC in TIV(P > 0.05).

In this research

BN(n = 34) HC(n = 34)

BN:22.85 (3.89) HC:22.26 (2.53)

VBM

Reduced GMV in the SFGmed. L, STG. R, DCG. R, DCG. L and SFGdor. L (BN < HC).

There were no significant differences between patients and controls in total GMV, WMV or TIV(P > 0.05).

Marsh et.al(2015) [6] Biol Psychiatry. 2015;77 (7):616–23

BN(n = 34) HC(n = 34)

BN:21.6 (6.0) HC:22.08 (6.5)

Morphological analysis including VBM and Cortical Thickness

Increased GMV in lingual gyri and inferior parietal lobule in BN (BN > HC); reduced GMV in bilateral medial frontal and precentral gyri, left superior and inferior frontal gyri, the right postcentral gyrus and bilateral temporoparietal areas (BN < HC).

The TIV did not differ across the BN and control group(P > 0.05).

Frank et.al(2016) [10] Transl Psychiatry. 2016;6 (11):e932

AN(n = 26) BN(n = 25) HC(n = 26)

AN:23.23 (5.26) BN:24.64 (4.22) HC:24.39 (3.49)

Structural and effective connectivity

Greater structural connectivity in insula, orbitofrontal cortex and ventral striatum (BN > HC), but lower connectivity in orbitofrontal cortex, amygdala and hypothalamus in BN (BN < HC).

Not assessed

Berner et al.(2018) [9] J Psychiatry Neurosci. 2018;43 (3):151–160

BN(n = 28) HC(n = 21)

BN:18.8 (4.1) HC:19.2 (5.5)

Cortical thickness

Greater cortical thickness in the left ventral posterior cingulate cortex in BN (BN > HC); reduced thickness of the right pars triangularis, right superior parietal and left dorsal posterior cingulate cortices (BN < HC).

Not assessed

Westwater et.al(2018) [8] Psychiatry Res Neuroimaging. 2018;271:118–125

BN(n = 37)

BN:22.6 (4.1)

Cortical thickness and structural connectivity

The cortical thickness in the left middle frontal gyrus, right superior frontal gyrus and bilateral orbitofrontal cortex (OFC) and temporoparietal regions negtively related to the severity of BN symptoms. The structural connectivity in the left OFC and middle temporal cortex negtively related to the severity of symptoms, while in the right superior parietal lobule positively related to the severity of symptoms.

Not assessed