From: Altered regional gray matter volume in Chinese female patients with bulimia nervosa
Authors&Journal | Participants | Mean Age (SD) | Method | Findings | |
---|---|---|---|---|---|
Regional Differences | Total Volume Difference | ||||
Schäfer et.al (2010) [4] Neuroimage. 2010;50 (2):639–43 | BN(n = 14) BED(n = 17) HC(n = 19) | BN:23.1 (3.8) BED:26.4 (6.4) HC:22.3 (2.6) | VBM | Increased GMV of the medial OFC and the ventral striatum in BN (BN > HC). | Not assessed |
Frank et.al(2013) [5] Am J Psychiatry. 2013;170 (10):1152–60 | AN(n = 19) Recovered AN(n = 24)BN(n = 20) HC(n = 24) | AN:23.1 (5.8) Recovered AN:30.3 (8.1) BN:25.2 (5.3) HC:27.4 (6.3) | VBM | Increased GMV in the Left orbitofrontal cortex and anterior ventral insula (BN > HC);reduced GMV in the bilateral dorsal caudate and dorsal putamen in BN (BN < HC). | There was no significant difference between BN and HC in GMV, WMV and TIV(P > 0.05). |
Coutinho et.al(2015) [7] Int J Eat Disord. 2015;48 (2):206–14 | BN(n = 21) HC(n = 20) | BN:31.57 (8.27) HC:30.90 (8.79) | VBM | Reduced volume of caudate nucleus in BN (BN < HC). | There was no significant difference between BN and HC in TIV(P > 0.05). |
In this research | BN(n = 34) HC(n = 34) | BN:22.85 (3.89) HC:22.26 (2.53) | VBM | Reduced GMV in the SFGmed. L, STG. R, DCG. R, DCG. L and SFGdor. L (BN < HC). | There were no significant differences between patients and controls in total GMV, WMV or TIV(P > 0.05). |
Marsh et.al(2015) [6] Biol Psychiatry. 2015;77 (7):616–23 | BN(n = 34) HC(n = 34) | BN:21.6 (6.0) HC:22.08 (6.5) | Morphological analysis including VBM and Cortical Thickness | Increased GMV in lingual gyri and inferior parietal lobule in BN (BN > HC); reduced GMV in bilateral medial frontal and precentral gyri, left superior and inferior frontal gyri, the right postcentral gyrus and bilateral temporoparietal areas (BN < HC). | The TIV did not differ across the BN and control group(P > 0.05). |
Frank et.al(2016) [10] Transl Psychiatry. 2016;6 (11):e932 | AN(n = 26) BN(n = 25) HC(n = 26) | AN:23.23 (5.26) BN:24.64 (4.22) HC:24.39 (3.49) | Structural and effective connectivity | Greater structural connectivity in insula, orbitofrontal cortex and ventral striatum (BN > HC), but lower connectivity in orbitofrontal cortex, amygdala and hypothalamus in BN (BN < HC). | Not assessed |
Berner et al.(2018) [9] J Psychiatry Neurosci. 2018;43 (3):151–160 | BN(n = 28) HC(n = 21) | BN:18.8 (4.1) HC:19.2 (5.5) | Cortical thickness | Greater cortical thickness in the left ventral posterior cingulate cortex in BN (BN > HC); reduced thickness of the right pars triangularis, right superior parietal and left dorsal posterior cingulate cortices (BN < HC). | Not assessed |
Westwater et.al(2018) [8] Psychiatry Res Neuroimaging. 2018;271:118–125 | BN(n = 37) | BN:22.6 (4.1) | Cortical thickness and structural connectivity | The cortical thickness in the left middle frontal gyrus, right superior frontal gyrus and bilateral orbitofrontal cortex (OFC) and temporoparietal regions negtively related to the severity of BN symptoms. The structural connectivity in the left OFC and middle temporal cortex negtively related to the severity of symptoms, while in the right superior parietal lobule positively related to the severity of symptoms. | Not assessed |