Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

BMC Psychiatry

Table 3 Differential metabolic pathways identified by MPEA between the V.SC and NV.SC groups

Pathway	Up	Down	p_hyper
Glycerolipid metabolism	Glycerol	Glycerol 3-phosphate	0.01
Phenylalanine, tyrosine and tryptophan biosynthesis		4-Hydroxyphenylpyruvic acid	0.045
Tyrosine metabolism	Vanillylmandelic acid	4-Hydroxyphenylpyruvic acid	0.08
Ubiquinone and other terpenoid-quinone biosynthesis		4-Hydroxyphenylpyruvic acid	0.10
Pentose phosphate pathway		D-Ribose	0.23
Galactose metabolism	Glycerol		0.27
Cysteine and methionine metabolism		L-Methionine	0.31
Glycerophospholipid metabolism		Glycerol 3-phosphate	0.35
Arginine and proline metabolism		4-Hydroxyproline	0.36
Purine metabolism		Uric acid	0.55

Abbreviation: MPEA metabolic pathway enrichment analysis, V.SC schizophrenia patients with violence, NV.SC schizophrenia patients without violence

ISSN: 1471-244X