From: Attitudes of European physicians towards the use of long-acting injectable antipsychotics
Questionnaire Item | Disagree (against LAI use, %) | Neither (%) | Agree (pro-LAI use, %) |
---|---|---|---|
Factor 1 – “Barriers” α = 0.87 31.4% of variance | |||
Reduced degree of prescriber autonomy (e.g. restricted formulary or special application necessary to start LAI) | 35.3 | 51.5 | 13.2 |
Higher loading dose or a booster injection required first | 28.7 | 61.8 | 9.5 |
Problems with LAI cost and/ or reimbursement | 43.4 | 45.6 | 11.0 |
Low test dose required first to check for tolerability | 29.4 | 50.0 | 20.6 |
Oral supplementary treatment required over the first 2–3 weeks | 37.5 | 47.1 | 15.4 |
Limitation to a particular injection frequency (i.e. only possible every 4 weeks and not flexible frequency) | 39.7 | 41.2 | 19.1 |
Risk of increasing stigma faced by the patient | 29.4 | 52.2 | 18.4 |
Therapeutic effect of the first injection is delayed | 44.1 | 43.4 | 12.5 |
Factor 2 – “Injection-specific barriers” α = 0.72 11.5% of variance | |||
Lack of availability of a nurse | 41.2 | 51.5 | 7.4 |
Choice of only gluteal for injection site | 47.8 | 41.2 | 11.0 |
Necessity of reconstitution of the compound before it is injected | 39.0 | 52.9 | 8.1 |
Factor 3 – “Balancing evidence of benefits” α = 0.60 7.5% of variance | |||
Evidence from clinical trials for efficacy of LAIs compared with oral antipsychotics | 5.9 | 22.1 | 72.1 |
Preserving the patient’s autonomy | 25.0 | 32.4 | 42.6 |
EFFICACY: Symptom reduction | 5.2 | 31.6 | 63.2 |
Factor 4 – “Positive expectations” α = 0.63 6.4% of variance | |||
Current gastrointestinal disease with absorption problemsa | 9.6 | 23.7 | 66.7 |
Patient request for LAIa | 0.7 | 9.6 | 89.6 |
EFFICACY: Relapse reduction | 2.9 | 7.4 | 89.7 |
Factor 5 – “Influence of colleagues” α = 0.91 4.8% of variance | |||
Negative attitude of peer psychiatrist colleagues in your department | 14.7 | 69.9 | 15.4 |
Negative attitude of other colleagues in your clinical team | 13.2 | 71.3 | 15.4 |
Factor 6 – “Needle fear/anxiety” α = 0.77 4.5% of variance | |||
Anticipatory anxiety for pain | 54.4 | 37.5 | 8.1 |
Patient’s fear of needles | 69.9 | 22.8 | 7.3 |