Inclusion criteria | Exclusion Criteria |
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- Aged between 18 and 75 years - No intake of any psychotropic medication/substance for a minimum of 2 months before study day 1. - For the inclusion of patients, a wide spectrum of affective, anxiety and stress-related mental disorders according to the criteria of DSM-IV or DSM-5 [2, 14] are allowed, specifically these are: Depressive disorders; Anxiety and obsessive-compulsive disorders: agoraphobia with and without panic disorder, panic disorder, social phobia, specific phobia, generalized anxiety disorder, obsessive compulsive disorder; Stress and trauma-associated mental disorders (e.g. posttraumatic stress disorder). | - Current illness in the field of organic mental disorders; - Affective disorders caused by a medical condition - Organic mental disorders (e.g. dementia) - Current disorders of schizophrenia; - Current eating disorder; - Mental retardation and profound developmental disorders; - Severe neurological or internal medical illness; - Posttraumatic or post-ischemic brain damage or elapsed cerebral hemorrhage; - Acute suicidality; - Pregnancy and postpartum period; - Magnetic resonance imaging contraindications (e.g. non-MR compatible metal implants including cardiac pacemakers, claustrophobia); - Myopia <− 6 D, which cannot be compensated by contact lenses or MR compatible glasses (Cambridge Research Systems, Rochester, UK); - Current substance abuse; - Current or past substance dependence; Risky alcohol consumption, screened with the Alcohol Use Disorder Identification Test – Consumption questions (AUDIT-C) [17] and defined as score of ≥5 in males and of ≥4 in females [18]. |