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Table 1 Eligibility criteria for participation in BeCOME

From: The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes

Inclusion criteria

Exclusion Criteria

- Aged between 18 and 75 years

- No intake of any psychotropic medication/substance for a minimum of 2 months before study day 1.

- For the inclusion of patients, a wide spectrum of affective, anxiety and stress-related mental disorders according to the criteria of DSM-IV or DSM-5 [2, 14] are allowed, specifically these are:

Depressive disorders;

Anxiety and obsessive-compulsive disorders: agoraphobia with and without panic disorder, panic disorder, social phobia, specific phobia, generalized anxiety disorder, obsessive compulsive disorder;

Stress and trauma-associated mental disorders (e.g. posttraumatic stress disorder).

- Current illness in the field of organic mental disorders;

- Affective disorders caused by a medical condition

- Organic mental disorders (e.g. dementia)

- Current disorders of schizophrenia;

- Current eating disorder;

- Mental retardation and profound developmental disorders;

- Severe neurological or internal medical illness;

- Posttraumatic or post-ischemic brain damage or elapsed cerebral hemorrhage;

- Acute suicidality;

- Pregnancy and postpartum period;

- Magnetic resonance imaging contraindications (e.g. non-MR compatible metal implants including cardiac pacemakers, claustrophobia);

- Myopia <− 6 D, which cannot be compensated by contact lenses or MR compatible glasses (Cambridge Research Systems, Rochester, UK);

- Current substance abuse;

- Current or past substance dependence;

Risky alcohol consumption, screened with the Alcohol Use Disorder Identification Test – Consumption questions (AUDIT-C) [17] and defined as score of ≥5 in males and of ≥4 in females [18].