Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial

Table 1 Overview of interventions, assessments, and timepoints

		Study Period
	Enrolment	Baseline	Intervention	Follow-up assessments
Timepoint	-t₁	T₀	T_intervention	T₁	T₂	T₃	T₄
		Week 0	Week 1–6	Week 7	Week 26	Week 39	Week 52
Erolment:
Eligibility screen	X
Informed consent	X
Allocation		X
Interventions:
*Cognitive Behavioral Therapy for Insomnia (CBT-I)*			X
*Chronobiological Therapy (CT)*			X
*Combination of CBT-I & CT*			X
*Treatment as Usual*			X
Assessments:
*Demographics*		X
*CIDI-SF*¹		X					X
*IDS-SR*²		X		X	X	X	X
*HADS*³		X		X	X	X	X
*PANAS*⁴		X		X	X	X	X
*Actigraphy*		X		X			X
*CSD*⁵		X	X	X			X
*ISI*⁶	X	X		X	X	X	X
*PSQI*⁷		X
*DSISD*⁸		X
*Sleep history*		X
*MCTQ*⁹		X
*rMEQ*¹⁰		X
*ITQ*¹¹	X				X		X
*BAI*¹²		X		X	X	X	X
*LES-B*¹³		X			X	X	X
*CTQ*¹⁴		X
*TIC-P*¹⁵		X					X
*Baecke*		X
*Compliance*			X
*Use of interventions*					X	X	X
*Health care use*					X	X	X
*MRI*¹⁶		X		X

¹ Composite International Diagnostic Interview – Short Form, ² Inventory of Depressive Symptoms – Self Report, ³ Hospital Anxiety and Depression Scale, ⁴ Positive Affect Negative Affect Scale, ⁵ Consensus Sleep Diary, ⁶ Insomnia Severity Index, ⁷ Pittsburgh Sleep Quality Index, ⁸ Duke Structured Interview for Sleep Disorders, ⁹ Munich Chronotype Questionnaire, ¹⁰ reduced Morningness-Eveningness Questionnaire, ¹¹ Insomnia Type Questionnaire, ¹² Becks Anxiety Inventory, ¹³ Life Experience Survey, ¹⁴ Childhood Trauma Questionnaire, ¹⁵ Trimbos and iMTA questionnaire on Costs associated with Psychiatric Illness, ¹⁶Magnetic Resonance Imaging

ISSN: 1471-244X