Table 3 Lithium and Neutrophils
From: Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
Physiological effects | Enhances production of endogenous G-CSF, directly stimulating differentiation of stem cells and protecting neutrophils from the toxicity of some drugs, although to a far smaller extent than G-CSF. |
Haematological usage | Reports of use to treat idiopathic neutropenia [71] |
Lithium and clozapine rechallenge | Reviews by Manu (2012) [72] and Boazak (2019) [73] show high rates of success. |
Adverse effects in clozapine rechallenge | Isolated case reports of failure / fatality [74] and of neurotoxicity [75] |
Use, dose, side effects | Familiar to psychiatrists |
Institutional / systemic factors | Systemic difficulties not likley |