Table 4 Neurodevelopmental and neuropsychiatric morbidity (NE, not evaluated)
Phenotype | II-1 (Proband) | II-2 (8 yo male) | II-3 (4 yo male) | I-1 (39 yo male) | Reported Frequency in 3q29 deletion syndrome |
|---|---|---|---|---|---|
General psychopathology | ADHD, combined type | ADHD, Combined type; Disruptive Mood Dysregulation Disorder; Conduct Disorder with Childhood Onset | ADHD, hyperactive type | ADHD, inattentive type | ADHD: NE |
Prodrome/psychosis | – | Attenuated Psychosis Syndrome | NE | Schizoaffective disorder | Psychosis: 5%3 |
Executive function T-score (%tile) | Clinically Significant Deficits 86 (> 99) | Clinically Significant Deficits 88 (> 99) | NE | Clinically Significant Deficits 73 (97) | NE |
Adaptive behavior Standard Score (%tile) | Significant Delays 65 (1) | Significant Delays 59 (< 1) | Significant Delays 68 (2) | Significant Delays 61 (< 1) | Global Devel Delay 41%3 |
Visual-motor integration Standard Score (%tile) | Average Range 92 (30) | Significant Delays 77 (6) | Low 83 (13) | Low 83 (13) | NE |
Anxiety | – | Separation Anxiety; Specific Phobia of the Dark | NE | Panic disorder; social anxiety disorder | Anxiety: 19%3 |
Autism | – | – | – | – | Autism: 26%3 |
Cognitive Ability Standard Score (%tile) | Below Average 82 (12) | Low 79 (8) | Average 96 (39) | Average 94 (34) | Intellectual disability: 92%2 |