| Variables | N | Deaths | Person- years | Incidence rate | Age and sex -adjusted | Multivariate-adjusteda | Multivariate-adjustedb |
|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) |
|---|
| Baseline MMSE score | | | | | 0.91 (0.88, 0.94)*** | 0.91 (0.88, 0.94)*** | 0.93 (0.90, 0.97)*** |
| Baseline cognitive status |
| Normal | 779 | 108 | 5244.40 | 20.59 | 1.00 | 1.00 | 1.00 |
| Impaired | 142 | 52 | 849.34 | 61.22 | 2.60 (1.81, 3.73) *** | 2.53 (1.76, 3.65)*** | 2.08 (1.43, 3.01)*** |
| Total | 921 | 160 | 6093.74 | 26.26 | | | |
| One-year transition in cognitive status |
| Normal-normal | 393 | 31 | 2368.37 | 13.09 | 1.00 | 1.00 | 1.00 |
| Normal-impaired | 55 | 9 | 315.73 | 28.51 | 2.19 (1.02, 4.71)* | 2.36 (1.07, 5.19)* | 2.01 (0.88, 4.59) |
| Impaired-normal | 31 | 9 | 168.36 | 53.46 | 3.27 (1.51, 7.09)** | 3.60 (1.64, 7.90)** | 2.87 (1.25, 6.56)* |
| Impaired-impaired | 38 | 13 | 196.41 | 66.19 | 4.83 (2.29, 10.15)** | 5.26 (2.45, 11.32)*** | 3.79 (1.64, 8.73)** |
- *: p < 0.05; **: p < 0.01; ***: p < 0.001
- Incidence rate (number of incident cases) / (1000 person-years), HR Hazard ratio, CI Confidence interval
- aMultivariate adjustment for age, sex, education, marital status, BMI, smoking, alcohol drinking, physical activity and exercising program
- bMultivariate adjustment for age, sex, education, marital status, BMI, smoking, alcohol drinking, physical activity, exercising program, hypertension, diabetes mellitus, heart disease, hyperlipidemia, gout, hyperuricemia, arthritis, osteoporosis, stroke, cataract, cancer, fall history, sleep disturbance and frailty
