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Table 2 Research questions- tobacco use

From: Gaps and challenges: WHO treatment recommendations for tobacco cessation and management of substance use disorders in people with severe mental illness

For people with SMD who use tobacco, are pharmacological (including nicotine replacement therapy, bupropion, varenicline) and/or non-pharmacological interventions effective to support tobacco cessation?
Population/ Intervention / Comparison / Outcome (PICO)
Population: People with SMD who use tobacco
• Pharmacological interventions: including nicotine replacement therapy (NRT), bupropion, varenicline
• Non-pharmacological interventions
Comparison: care as usual and/or placebo
• Critical
o Tobacco cessation/abstinence rates
o Tobacco consumption rates
o Respiratory disease outcomes (COPD, asthma)
• Important:
o Frequency of adverse events/side-effects