Table 2 Research questions- tobacco use

For people with SMD who use tobacco, are pharmacological (including nicotine replacement therapy, bupropion, varenicline) and/or non-pharmacological interventions effective to support tobacco cessation?

Population/ Intervention / Comparison / Outcome (PICO)

Population: People with SMD who use tobacco

Intervention:

• Pharmacological interventions: including nicotine replacement therapy (NRT), bupropion, varenicline

• Non-pharmacological interventions

Comparison: care as usual and/or placebo

Outcomes:

• Critical

o Tobacco cessation/abstinence rates

o Tobacco consumption rates

o Respiratory disease outcomes (COPD, asthma)

• Important:

o Frequency of adverse events/side-effects