Table 2 Comparative analysis of patients with normal and prolonged QTc interval
Variables | QTc interval | p-value | |
|---|---|---|---|
Normal (N = 382) a n (%) | Prolonged (N = 23) b n (%) | ||
Gender | |||
 Male | 229 (92.3) | 19 (7.7) | 0.03 |
 Female | 153 (97.5) | 4 (2.5) | |
Age (years) | |||
  ≤ 20 | 75 (19.6) | 6 (26.1) | 0.45 |
 21–30 | 105 (27.5) | 4 (17.4) | |
 31–40 | 94 (24.6) | 4 (17.4) | |
  > 40 | 108 (28.3) | 9 (39.1) | |
All prescribed drugs | |||
 1 | 47 (12.3) | 1 (4.3) | 0.48 |
 2–3 | 240 (62.8) | 15 (65.2) | |
  > 3 | 95 (24.9) | 7 (30.4) | |
QT prolonging drugs | |||
 1 | 216 (56.5) | 10 (43.5) | 0.22 |
  ≥ 2 | 166 (43.5) | 13 (56.5) | |
QT drug-drug interactions | 109 (28.5) | 9 (39.9) | 0.27 |
Diagnosis | |||
 Psychosis | 29 (7.6) | 2 (8.7) | 0.84 |
 Manic depressive psychosis | 33 (8.6) | 10 (13) | 0.47 |
 Obsessive compulsive disorder | 16 (4.2) | 2 (8.7) | 0.30 |
 Schizophrenia | 16 (4.2) | 1 (4.3) | 0.97 |
 Major depression | 200 (52.4) | 11 (47.8) | 0.67 |
 Hypomania | 13 (3.4) | 0 (0) | 0.36 |
 Panic disorder | 34 (8.9) | 0 (0) | 0.13 |
 Bipolar affective disorder | 11 (2.9) | 0 (0) | 0.40 |
 Substance abuse | 17 (4.9) | 0 (0) | 0.30 |
Co-morbid illnesses | |||
 Hypertension | 40 (10.5) | 3 (13) | 0.67 |
 Diabetes mellitus | 17 (4.5) | 0 (0) | 0.80 |
 Epilepsy | 13 (3.4) | 0 (0) | 0.27 |
QT prolonging drug classes (ATC Code) | |||
 Antipsychotic (N05A) | 140 (36.6) | 11 (47.8) | 0.28 |
 Proton pump inhibitors (A02BC) | 48 (12.6) | 1 (4.3) | 0.24 |
 Antidepressant (N06A) | 253 (66.2) | 14 (60.9) | 0.59 |
 Other drugs | 19 (5) | 2 (8.7) | 0.43 |