Receptor | Author, year | Conclusions |
---|---|---|
D1 | Ogren SO, 1988 [36] Salmi P, 1994 [37] | The D1/2 receptor agonist apomorphine and the D2 agonist pergolide induced hypothermia in rats, which was prevented by the use of sulpiride, a D2 antagonist. |
Hypothermia produced by clozapine was fully antagonized by the selective D1 receptor antagonist SCH-23390. | ||
D2 | Zarrindast MR, 1989 [38] Boulay D, 1999 [39] | Bromocriptine, a D2 agonist, caused dose-dependent decreases in the core body temperature of mice. This effect was mitigated by pretreatment with sulpiride |
The preferential D2/3 receptor agonists 7-OH-DPAT and PD 128907 induced hypothermia in D2 (+/+) mice, but not in D2 knockout mice. | ||
D3 | Millan MJ, 1995 [40] Perachon S, 2000 [41] Varty GB, 1998 [42] | Similar to (+)-7-OH-DPAT, clozapine dose-dependently elicited hypothermia in rats. The D3-selective antagonist (+/−)-S 11566 blocked clozapine-induced hypothermia. |
(+)-7-OH-DPAT was effective in inducing hypothermia in both D3 (+/+) and D3 knockout mice, suggesting the D3 receptor is not responsible for hypothermia. | ||
Raclopride (D2/3 antagonist) blocked (+)-7-OH-DPAT induced hypothermia. | ||
Alpha-1 | Boschi G, 1987 [43] | Phenothiazines, butyrophenones, and benzamides (alpha-1 antagonists) injected intraperitoneally demonstrated induced-hypothermia, whereas intracerebovascular administration did not. The administration of phenylephrine (alpha-1 agonist) attenuated hypothermia. |
5HT1A | Gudelsky GA, 1986 [44] Abdel-Fattah AF, 1995 [45] Neves G, 2008 [46] | The 5HT1A agonist 8-OH-DPAT induced dose-related decreased in temperature in rats. |
Pindolol, a 5HT1A antagonist, suppressed tryptophan (serotonin precursor) induced hypothermia in pargyline-treated mice. | ||
The hypothermia produced by the N-phenylpiperazine derivatives LASSBio-579 and LASSBio-581 was diminished by the 5-HT1A antagonist WAY 100635. | ||
5HT2A/C | Yamada J, 1995 [47] Murphy TJ, 2019 [48] Gudelsky GA, 1986 [44] | The centrally acting 5HT2A/C agonist I-2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited haloperidol and chlorpromazine-induced hypothermia. |
The selective 5HT2C agonist WAY-163909 inhibited ketamine-induced hypothermia, whereas DOI did not. | ||
MK-212 (5HT2 agonist) induced hyperthermia, while mianserin (5HT2 antagonist) blocked hyperthermia caused by MK-212 in rats. | ||
5HT7 | Hedlund PB, 2010 [49] Naumenko VS, 2011 [50] | LP-211 (5HT7 selective agonist) induced hypothermia in 5HT7 (+/+) mice, but not 5HT7 receptor knockout mice. |
The selective 5HT7 receptor antagonist SB 269970 inhibited centrally administered LP-44 (5HT7 agonist) induced hypothermia. Intraperitoneal administration of LP-44 did not induce hypothermia. | ||
M3 | Black CE, 2001 [51] Golding JF, 2018 [52] | M3 antagonism via hyoscine hydrobromide may induce hyperthermia through decreased skin conductance and vasoconstriction, reducing heat loss and sweating. |
Neurotensin-1 receptor (NTS-1) | Feifel D, 2010 [53] | PD149163, a selective, brain-penetrating, NT1 receptor agonist produced hypothermia in rats. |