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Fig. 4 | BMC Psychiatry

Fig. 4

From: A randomized controlled trial comparing the clinical efficacy and cost-effectiveness of eye movement desensitization and reprocessing (EMDR) and integrated EMDR-Dialectical Behavioural Therapy (DBT) in the treatment of patients with post-traumatic stress disorder and comorbid (Sub)clinical borderline personality disorder: study design

Fig. 4

Relationship between treatment condition (i.e. EMDR, EMDR-DBT) and primary outcome measures (i.e. post-treatment scores on the CAPS-5 and SCID-5-PD), proposedly mediated by pre-to post-stressor changes in levels of cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status. It is hypothesized that the regression of the primary outcome measures on treatment condition, ignoring the mediators, will be significant (c1). Secondly, the regression of the mediators cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status on treatment condition are hypothesized to be significant as well (a1, a2 and a3 resp.). In addition, the regression of the primary outcome measures on the mediators are also expected to be significant (b1, b2 and b3 resp.). Lastly, it is hypothesized that, when controlling for the mediators, treatment condition will significantly predict the scores on the CAPS-5 and SCID-5-PD, supporting partial mediation

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