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Table 2 Serum concentrations of amino acids between healthy controls and MDD patients

From: Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder

Amino acids

MDD patients (n = 247)

Healthy controls (n = 248)

 

(μmol/L)

Median

Q1-Q3

Median

Q1-Q3

p value

Alanine

233

202–492

238

203–502

0.065

Arginine

65.42

37.5–107

70.3

22.3–144

0.725

Aspartic acid

4.56

2.21–7.03

5.1

2.32–8.03

0.479

Cysteine

154

91.4–222

157

84.6–217

0.134

Glutamic acid

56.7

37.43–78.5

52.5

29.45–103

0.456

Glycine

205

114–476

210

104–464

0.107

Histidine

70.32

26.47–105

70.5

25.32-140

0.358

Isoleucine

51.3

41.94–80.7

53.6

37.43–99.4

0.212

Leucine

101

91.4–130

104

88.6–150

0.127

Lysine

159

92.1–305

157

90.3–290

0.837

Methionine

22.2

13.54–33.8

22.54

15.43–39.89

0.004a

Phenylalanine

64.8

54.41–93.73

69.7

53.58–115

< 0.001b

Proline

147

69.59–333

159

67.82–357

0.263

Serine

109

59.63–175

104

64.45–190

0.927

Threonine

128

62.52–210

136

65.73–206

0.088

Tryptophan

47.52

33.84–76.6

52.26

36.81–98.17

< 0.001c

Tyrosine

58.28

31.16–81.43

60.53

34.42–109

0.011d

Valine

196

156–311

189

149–309

0.752

  1. p values from Mann-Whitney U test, p is significant at the 0.05 level, a Bonferroni-corrected p value < 0.05: patients < controls (p = 0.007), b Bonferroni-corrected p value < 0.05: patients < controls (p < 0.001), c Bonferroni-corrected p value < 0.05: patients < controls (p < 0.001), d Bonferroni-corrected p value < 0.05: patients < controls (p = 0.018)
  2. Q1 lower quartile, Q3 upper quartile
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BMC Psychiatry

ISSN: 1471-244X

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