Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report

BMC Psychiatry

Table 1 Comparison of comorbid psychiatric symptoms with MLC in previous reports and present study

Author (Year)	Country (Race)	Onset		Mental retardation	Convulsions	Cysts	Psychiatric symptoms	Gene mutation
		Neurological symptoms	Psychiatric symptoms	Mental retardation	Convulsions	Cysts	Psychiatric symptoms	Gene mutation
Blattner [3] (2003)	UK	Early childhood	Late 20s	Mild form 9 years old	+	Bilateral temporal lobe	Depressive state, agitation	Not investigated
Blattner [3] (2003)	(Caucasian)	Early childhood	Late 20s	Mild form 9 years old	+	Bilateral temporal lobe	Depressive state, agitation	Not investigated
Bugiani [5] (2003)	Italy	6 years	12 years		+	Bilateral temporal lobe	Coma	GT to AT^*1
Bugiani [5] (2003)	(NA)	6 years	12 years		+	Bilateral temporal lobe	Coma	GT to AT^*1
Sugiura [6] (2006)	Japan	Early childhood	12 years	Mild	+	Bilateral frontal and temporal lobes	Obsessive-compulsive symptoms	Ser280 → Leu
Sugiura [6] (2006)	(Asian)	Early childhood	12 years	Mild	+	Bilateral frontal and temporal lobes	Obsessive-compulsive symptoms	Ser280 → Leu
Present case	Japan (Asian)	Early childhood	17 years	Mild	+	Left anterior temporal lobe	Mood swings, catatonia	S93L

ISSN: 1471-244X