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Table 4 Performance of the Patient Health Questionnaire 9-item (PHQ-9) and Patient Health Questionnaire 2-item (PHQ-2) Screening Tools to Detect Major Depressive Disorder Among Primary Care Patients in Sofala, Mozambique

From: Validity and item response theory properties of the Patient Health Questionnaire-9 for primary care depression screening in Mozambique (PHQ-9-MZ)

PHQ-9

PHQ-2

Cut-point

Sens

Spec

% Classified

LR+

LR-

DOR

PPV

NPV

Sens

Spec

% Classified

LR+

LR-

DOR

PPV

NPV

≥0

100.0%

0.0%

8.6%

1.00

    

100.0%

0.0%

8.6%

1.00

    

≥1

95.4%

15.7%

22.5%

1.13

0.30

3.80

0.10

0.97

90.7%

38.3%

42.7%

1.47

0.24

6.04

0.12

0.98

≥2

90.7%

26.5%

32.0%

1.23

0.35

3.52

0.10

0.97

74.4%

71.7%

72.0%

2.63

0.36

7.38

0.20

0.97

≥3

90.7%

42.8%

46.9%

1.59

0.22

7.30

0.13

0.98

32.6%

94.6%

89.3%

5.99

0.71

8.40

0.36

0.94

≥4

86.1%

57.2%

59.6%

2.01

0.24

8.23

0.16

0.98

25.6%

98.7%

92.5%

19.61

0.75

26.01

0.65

0.93

≥5

79.1%

68.3%

69.2%

2.49

0.31

8.13

0.19

0.97

        

≥6

72.1%

78.7%

78.1%

3.38

0.35

9.54

0.24

0.97

18.6%

98.9%

92.1%

17.12

0.82

20.80

0.61

0.93

≥7

60.5%

86.3%

84.1%

4.41

0.46

9.64

0.29

0.96

0.0%

100.0%

91.5%

 

1.00

  

0.91

≥8

53.5%

91.5%

88.3%

6.31

0.51

12.41

0.37

0.95

        

≥9

46.5%

93.5%

89.5%

7.13

0.57

12.46

0.40

0.95

        

≥10

34.9%

95.7%

90.5%

8.02

0.68

11.79

0.43

0.94

        

≥11

34.9%

96.3%

91.1%

9.44

0.68

13.96

0.47

0.94

        

≥12

30.2%

97.2%

91.5%

10.70

0.72

14.90

0.50

0.94

        

≥13

25.6%

98.3%

92.1%

14.71

0.76

19.42

0.58

0.93

        

≥14

23.3%

98.3%

91.9%

13.37

0.78

17.12

0.56

0.93

        

≥15

20.9%

98.5%

91.9%

13.75

0.80

17.13

0.56

0.93

        

≥16

18.6%

99.1%

92.3%

21.40

0.82

26.06

0.67

0.93

        

≥18

16.3%

99.1%

92.1%

18.72

0.84

22.17

0.64

0.93

        

≥19

16.3%

99.4%

92.3%

24.96

0.84

29.62

0.70

0.93

        

≥20

16.3%

99.6%

92.5%

37.44

0.84

44.53

0.78

0.93

        

≥21

14.0%

99.6%

92.3%

32.09

0.86

37.14

0.75

0.93

        

≥22

14.0%

99.8%

92.5%

64.19

0.86

74.44

0.86

0.93

        

≥24

14.0%

100.0%

92.6%

 

0.86

 

1.00

0.93

        

≥25

9.3%

100.0%

92.3%

 

0.91

 

1.00

0.92

        

≥27

7.0%

100.0%

92.1%

 

0.93

 

1.00

0.92

        

> 27

0.0%

100.0%

91.5%

 

1.00

  

0.91

        

Area Under ROC curve: 0.809 (95% CI: 0.731, 0.887)

Area Under ROC curve: 0.777 (95% CI: 0.703, 0.851)

  1. Abbreviations: LR+ Likelihood Ratio Positive, LR- Likelihood Ratio Negative, DOR Diagnostic Odds Ratio, PPV Positive Predictive Value, NPV Negative Predictive Value, ROC Receiver Operating Characteristic, CI Confidence Interval