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Table 2 Association of serotonin-related gene polymorphisms with PD risk in Chinese Han population

From: The association between serotonin-related gene polymorphisms and susceptibility and early sertraline response in patients with panic disorder

Gene

SNP

Alleles and Genotypes

(n, %)

PD

(n = 233)

Controls

(n = 231)

Model

OR (95% CI)

p-value

p-valuecorr

SLC6A4

rs140701

C

76 (16.3)

110 (23.8)

Allelea

0.624 (0.450–0.864)

0.004

0.028

T

390 (83.7)

352 (76.2)

CC

10 (4.3)

13 (5.6)

Additiveb

0.638 (0.463–0.879)

0.009

0.063

CT

56 (24.0)

84 (36.4)

Dominantb

0.546 (0.371–0.804)

0.004

0.028

TT

167 (71.7)

134 (58.0)

Recessiveb

0.752 (0.323–1.751)

0.438

1

rs3813034

C

386 (82.8)

357 (77.3)

Allelea

0.705 (0.509–0.975)

0.034

0.238

A

80 (17.2)

105 (22.7)

CC

164 (70.4)

139 (60.2)

Additiveb

0.721 (0.526–0.988)

0.048

0.336

CA

58 (24.9)

79 (34.2)

Dominantb

0.636 (0.432–0.935)

0.025

0.175

AA

11 (4.7)

13 (5.6)

Recessiveb

0.831 (0.364–1.895)

0.662

1

5-HTTLPR

L

107 (23.0)

130 (28.1)

Allelea

0.761 (0.566–1.024)

0.071

0.497

S

359 (77.0)

332 (71.9)

LL

22 (9.4)

20 (8.7)

Additiveb

0.785 (0.594–1.039)

0.100

0.700

LS

63 (27.0)

90 (39.0)

Dominantb

0.632 (0.436–0.916)

0.021

0.147

SS

148 (63.5)

121 (52.3)

Recessiveb

1.100 (0.583–2.076)

0.842

1

STin2

10

44 (9.4)

43 (9.3)

Allelea

1.016 (0.653–1.580)

0.944

1

12

422 (90.6)

419 (90.7)

10/10

5 (2.1)

2 (0.9)

Additiveb

1.015 (0.663–1.554)

0.956

1

12/10

34 (14.6)

39 (16.9)

Dominantb

0.932 (0.575–1.508)

0.711

1

12/12

194 (83.3)

190 (82.2)

Recessiveb

2.511 (0.482–13.080)

0.393

1

HTRA1

rs6295

G

359 (77.0)

358 (77.5)

Allelea

1.026 (0.755–1.395)

0.870

1

C

107 (23.0)

104 (22.5)

GG

138 (59.2)

138 (59.7)

Additiveb

1.026 (0.754–1.398)

0.554

1

GC

83 (35.6)

82 (35.5)

Dominantb

1.022 (0.705–1.480)

0.560

1

CC

12 (5.2)

11 (4.8)

Recessiveb

1.086 (0.469–2.513)

0.772

1

HTR2A

rs6313

G

163 (35.0)

179 (38.7)

Allelea

0.868 (0.651–1.111)

0.234

1

A

303 (65.0)

283 (61.3)

AA

106 (45.5)

86 (37.2)

Additiveb

0.859 (0.663–1.113)

0.252

1

GA

91 (39.1)

111 (48.1)

Dominantb

0.711 (0.490–1.030)

0.061

0.427

GG

36 (15.4)

34 (14.7)

Recessiveb

1.059 (0.637–1.761)

0.749

1

COMT

rs4680

A

143 (30.7)

118 (25.5)

Allelea

1.291 (0.969–1.720)

0.081

0.567

G

323 (69.3)

344 (74.5)

AA

24 (10.3)

15 (6.5)

Additiveb

1.284 (0.65–1.707)

0.118

0.826

GA

95 (40.8)

88 (38.1)

Dominantb

1.297 (0.901–1.869)

0.175

1

GG

114 (48.9)

128 (55.4)

Recessiveb

1.654 (0.844–3.240)

0.236

1

  1. “A” represent wild type and “a” represent mutant type: allele, a vs. A; additive, aa vs. Aa vs. AA; dominant, aa + Aa vs. AA, recessive, aa vs. Aa +AA. a Chi-square test, b Logistic regression analyses by adjustment for age, gender, educational level and resident location. Pcorr: adjusted by boferroni multiple comparison correction