Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response

BMC Psychiatry

Table 3 Genetic association analysis (genotypic/allelic) of SNPs versus response status in each subgroups

Groups	SNPs (Gene/rs#)	Allele/Genotype	Response (%)	Non-response (%)	OR (95% CI)	χ²	P	P*
Total group	ApoE /rs405509	AA	113 (55)	28 (37)	1	7.411	0.006	0.04
Total group		AC	82 (40)	42 (55)	0.48 (0.28–0.84)	5.239	0.022
SNRI subgroup	ApoA4/rs5092	A	98 (54)	17 (33)	1	7.241	0.007	0.005
		G	84 (46)	35 (67)	0.42 (0.22–0.80)	7.241	0.007	0.005
		AA	23 (25)	2 (8)	1	3.721	0.054
		AG	62 (54)	32 (64)	0.63 (0.27–1.43)	1.313	0.252
		GG	16 (18)	11 (42)	0.13 (0.02–0.65)	6.964	0.008	0.019
SSRI subgroup	ApoA4 /rs5092	A	124 (54)	52 (52)	1	0.159	0.690
		G	104 (46)	48 (48)	0.91 (0.57–1.46)	0.159	0.690
		AA	31 (27)	10 (20)	1	0.959	0.327
		AG	62 (54)	32 (64)	0.63 (0.27–1.43)	1.313	0.252
		GG	21 (18)	8 (16)	0.85 (0.29–2.50)	0.14	0.708

Abbreviations: SNPs single nucleotide polymorphisms, SNRI serotonin norepinephrine reuptake inhibitor, OR odds ratio, CI confidence interval
*Adjusted P-value from 1000 permutation tests

ISSN: 1471-244X