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Table 5 Estimated haplotype frequencies of the two ApoE SNPs (rs7412 and rs405509) and the results of haplotype analysis in responders and non-responders

From: Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response

Group

haplotype

response (%)

non-response (%)

OR (95%CI)

χ2

P

P*

SSRI subgroups

rs7412-rs405509

      

A-C

23 (9)

6 (7)

0.65 (0.05–7.63)

0.605

0.437

 

G-A

169 (68)

54 (65)

0.48 (0.06–4.07)

0.263

0.608

 

G-C

46 (18)

21 (26)

0.33 (0.04–2.66)

2.389

0.122

 

SNRI subgroup

rs7412-rs405509

      

A-C

12 (7)

3 (5)

3.12 (0.23–42.27)

0.019

0.890

 

G-A

139 (77)

29 (55)

3.38 (0.57–19.42)

7.658

0.006

 

G-C

26 (14)

17 (33)

1.04 (0.19–5.64)

8.24

0.0041

0.049

  1. Abbreviations: RM remission; NR non-remission, SNRI serotonin noradrenaline reuptake inhibitor, OR odds ratio, CI confidence interval
  2. *Adjusted P-value from 1000 permutation tests
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BMC Psychiatry

ISSN: 1471-244X

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