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Table 3 Post-hoc analysis of impact of PRIME mental health care plan on individual level outcomes, excluding treatment participant who only received basic MHCP intervention

From: Impact of integrated district level mental health care on clinical and functioning outcomes of people with depression and alcohol use disorder in Nepal: a non-randomised controlled study

  Control group Counselling (HAP/CAP) group Adjusted β (95%CI) P Effect size
N Mean (SD) or N (%) Adjusted mean change (95%CI) from BL N Mean (SD) or N (%) Adjusted mean change (95%CI) from BL
Depression Cohort
 PHQ-9
  Baseline 72 12.3 (2.15) 60 13.0 (3.37)   
  Midline 49 6.3 (5.06) −6.33 (−7.77 to −4.89) 46 3.9 (3.56) −8.97 (−10.21 to − 7.72) −2.64 (− 4.55 to −0.74) 0.007 − 0.56 (− 0.96, − 0.16)
  Endline 55 6.6 (4.94) −5.50 (− 6.90 to − 4.11) 46 3.4 (2.95) −9.16 (− 10.44 to − 7.89) −3.66 (− 5.55 to − 1.77) < 0.001 − 0.76 (− 1.15, − 0.37)
 WHODAS
  Baseline 72 30.0 (15.55) 60 36.5 (15.50)   
  Midline 49 21.7 (18.50) − 6.89 (− 12.43 to − 1.35) 46 14.1 (15.81) −19.09 (− 24.27 to − 13.91) − 12.20 (− 19.79 to − 4.62) 0.002 −0.65 (− 1.05, − 0.25)
  Endline 55 22.8 (18.89) −5.78 (− 11.34 to − 0.22) 46 13.1 (15.35) −20.04 (− 26.33 to − 13.75) −14.26 (− 22.65 to − 5.86) 0.001 −0.67 (− 1.06, − 0.27)
AUD Cohort
 AUDIT
  Baseline 57 16.4 (6.53) 80 26.0 (6.46)   
  Midline 28 16.0 (5.92) 3.78 (0.57 to 6.98) 63 10.1 (9.55) −13.96 (− 17.88 to − 10.04) − 17.74 (− 22.80 to − 12.67) < 0.001 − 1.56 (− 2.00, − 1.11)
  Endline 35 16.9 (9.04) 2.75 (−1.72 to 7.22) 66 14.9 (11.08) −7.69 (− 12.30 to − 3.08) − 10.45 (− 16.87 to − 4.02) 0.001 − 0.67 (− 1.08, − 0.26)
 WHODAS
  Baseline 57 17.5 (15.11) 80 22.8 (18.64)   
  Midline 28 13.4 (12.58) −2.43 (− 8.09 to 3.24) 63 11.7 (14.37) −9.87 (− 15.15 to − 4.58) −7.44 (− 15.19 to 0.31) 0.060 −0.43 (− 0.87, 0.02)
  Endline 35 15.5 (13.03) 4.68 (− 2.97 to 12.34) 66 12.6 (14.14) − 8.39 (−14.03 to − 2.75) −13.08 (− 22.58 to − 3.57) 0.007 −0.56 (− 0.97, − 0.15)
  1. The inverse probability weights were recalculated based on baseline differences between the control and refined treatment groups in the depression and AUD cohorts, hence adjusted mean change values differ from Table 2
  2. AUDIT Alcohol use disorder identification test, BL Baseline, PHQ-9 Patient Health Questionnaire – 9 item, RR Risk ratio, SD Standard deviation, WHODAS WHO Disability Assessment Schedule