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Table 3 Post-hoc analysis of impact of PRIME mental health care plan on individual level outcomes, excluding treatment participant who only received basic MHCP intervention

From: Impact of integrated district level mental health care on clinical and functioning outcomes of people with depression and alcohol use disorder in Nepal: a non-randomised controlled study

 

Control group

Counselling (HAP/CAP) group

Adjusted β (95%CI)

P

Effect size

N

Mean (SD) or N (%)

Adjusted mean change (95%CI) from BL

N

Mean (SD) or N (%)

Adjusted mean change (95%CI) from BL

Depression Cohort

 PHQ-9

  Baseline

72

12.3 (2.15)

60

13.0 (3.37)

  

  Midline

49

6.3 (5.06)

−6.33 (−7.77 to −4.89)

46

3.9 (3.56)

−8.97 (−10.21 to − 7.72)

−2.64 (− 4.55 to −0.74)

0.007

− 0.56 (− 0.96, − 0.16)

  Endline

55

6.6 (4.94)

−5.50 (− 6.90 to − 4.11)

46

3.4 (2.95)

−9.16 (− 10.44 to − 7.89)

−3.66 (− 5.55 to − 1.77)

< 0.001

− 0.76 (− 1.15, − 0.37)

 WHODAS

  Baseline

72

30.0 (15.55)

60

36.5 (15.50)

  

  Midline

49

21.7 (18.50)

− 6.89 (− 12.43 to − 1.35)

46

14.1 (15.81)

−19.09 (− 24.27 to − 13.91)

− 12.20 (− 19.79 to − 4.62)

0.002

−0.65 (− 1.05, − 0.25)

  Endline

55

22.8 (18.89)

−5.78 (− 11.34 to − 0.22)

46

13.1 (15.35)

−20.04 (− 26.33 to − 13.75)

−14.26 (− 22.65 to − 5.86)

0.001

−0.67 (− 1.06, − 0.27)

AUD Cohort

 AUDIT

  Baseline

57

16.4 (6.53)

80

26.0 (6.46)

  

  Midline

28

16.0 (5.92)

3.78 (0.57 to 6.98)

63

10.1 (9.55)

−13.96 (− 17.88 to − 10.04)

− 17.74 (− 22.80 to − 12.67)

< 0.001

− 1.56 (− 2.00, − 1.11)

  Endline

35

16.9 (9.04)

2.75 (−1.72 to 7.22)

66

14.9 (11.08)

−7.69 (− 12.30 to − 3.08)

− 10.45 (− 16.87 to − 4.02)

0.001

− 0.67 (− 1.08, − 0.26)

 WHODAS

  Baseline

57

17.5 (15.11)

80

22.8 (18.64)

  

  Midline

28

13.4 (12.58)

−2.43 (− 8.09 to 3.24)

63

11.7 (14.37)

−9.87 (− 15.15 to − 4.58)

−7.44 (− 15.19 to 0.31)

0.060

−0.43 (− 0.87, 0.02)

  Endline

35

15.5 (13.03)

4.68 (− 2.97 to 12.34)

66

12.6 (14.14)

− 8.39 (−14.03 to − 2.75)

−13.08 (− 22.58 to − 3.57)

0.007

−0.56 (− 0.97, − 0.15)

  1. The inverse probability weights were recalculated based on baseline differences between the control and refined treatment groups in the depression and AUD cohorts, hence adjusted mean change values differ from Table 2
  2. AUDIT Alcohol use disorder identification test, BL Baseline, PHQ-9 Patient Health Questionnaire – 9 item, RR Risk ratio, SD Standard deviation, WHODAS WHO Disability Assessment Schedule