Fig. 1

Network graph. Summary of the evidence of the network comparing drugs versus placebos. The thickness of the lines is proportionate to the number of trials comparing each pair of drugs/placebos, and the size of each node is proportionate to the number of randomized participants (sample size); see Fig. S2 for details on the original network and Tab. S1 for details on sample sizes. Single-comparison placebos discussed in the main analysis, i.e., those assessed in two-arm trials, are highlighted (blue)