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Table 2 Subgroup analyses of changes in sleep onset latency recorded with the electronic sleep diary

From: Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders

Subgroups

Phases

Changesa

Wilcoxon’s signed rank sum test

n

Mean ± SD

95% CI

P value

Autism spectrum disorder

 Absent

Screening phase

–

–

–

–

Medication phase I

25

−36.2 ± 40.5

−53.0 to −19.5

<  0.0001

 Present

Screening phase

–

–

–

–

Medication phase I

74

−36.8 ± 48.1

−48.0 to −25.7

<  0.0001

ADHD

 Absent

Screening phase

–

–

–

–

Medication phase I

39

−42.7 ± 62.5

−62.9 to −22.4

< 0.0001

 Present

Screening phase

–

–

–

–

Medication phase I

60

−32.8 ± 31.2

−40.9 to −24.7

< 0.0001

Intellectual disabilities

 Absent

Screening phase

–

–

–

–

Medication phase I

77

−35.8 ± 44.6

−46.0 to −25.7

< 0.0001

 Present

Screening phase

–

–

–

–

Medication phase I

22

−39.7 ± 52.1

−62.8 to −16.6

< 0.0001

Motor disorders

 Absent

Screening phase

–

–

–

–

Medication phase I

90

−37.4 ± 47.9

−47.4 to −27.3

< 0.0001

 Present

Screening phase

–

   

Medication phase I

9

−29.8 ± 19.7

−45.0 to −14.6

0.0039

Specific learning disorder

 Absent

Screening phase

–

–

–

–

Medication phase I

93

−36.0 ± 47.1

−45.7 to −26.3

< 0.0001

 Present

Screening phase

–

–

–

–

Medication phase I

6

−46.8 ± 25.3

−73.4 to −20.3

0.0313

  1. a: Change = (median during the last 7 days of the medication phase I) - (median during the last 7 days of the screening phase)
  2. SD Standard deviation, CI Confidence interval, ADHD Attention-deficit/hyperactivity disorder