Table 3 Change in Body Weight and Cardiovascular Parameters During Long-term Treatment With GXR
Parameter | Patient population | Week 0 Mean (SD) | Mean (SD) change from week 0 at last observation in the treatment period |
|---|---|---|---|
Body weight, kg | Former placebo patients | 66.89 (15.1) | 0.12 (2.8) |
Former GXR patients | 67.34 (12.7) | −0.34 (4.4) | |
New patients | 68.40 (15.2) | −0.34 (3.4) | |
Pulse rate, bpm | Former placebo patients | 73.56 (8.5) | −5.60 (12.4) |
Former GXR patients | 72.94 (11.7) | −5.48 (9.8) | |
New patients | 77.22 (11.7) | −6.74 (11.8) | |
Systolic BP, mmHg | Former placebo patients | 115.39 (14.2) | −6.19 (11.9) |
Former GXR patients | 117.58 (13.2) | −7.31 (11.7) | |
New patients | 119.54 (16.9) | −8.27 (14.7) | |
Diastolic BP, mmHg | Former placebo patients | 72.38 (10.5) | −4.11 (10.1) |
Former GXR patients | 74.51 (11.2) | −6.88 (10.6) | |
New patients | 75.06 (14.0) | −6.52 (10.8) | |
ECG parameters | |||
Heart rate, bpm | Former placebo patients | 65.7 (8.5) | −7.9 (10.0) |
Former GXR patients | 63.5 (9.9) | −3.8 (9.5) | |
New patients | 69.30 (9.4) | −8.70 (12.4) | |
RR interval, msec | Former placebo patients | 926.0 (114.2) | 135.7 (165.3) |
Former GXR patients | 964.6 (147.3) | 72.9 (161.8) | |
New patients | 881.55 (134.5) | 134.30 (192.9) | |
PR interval, msec | Former placebo patients | 153.1 (20.5) | 3.1 (12.0) |
Former GXR patients | 149.2 (19.5) | 4.2 (11.6) | |
New patients | 150.87 (21.0) | 3.44 (15.3) | |
QRS interval, msec | Former placebo patients | 98.6 (10.4) | 0.5 (6.5) |
Former GXR patients | 100.7 (16.0) | −0.1 (6.4) | |
New patients | 98.58 (7.9) | 0.58 (5.7) | |
QT interval, msec | Former placebo patients | 396.9 (29.0) | 16.9 (25.9) |
Former GXR patients | 403.5 (24.3) | 4.6 (25.6) | |
New patients | 387.86 (28.3) | 17.05 (27.3) | |
QTcB, msec | Former placebo patients | 413.5 (23.3) | −9.9 (18.1) |
Former GXR patients | 413.1 (21.9) | − 9.5 (16.8) | |
New patients | 414.85 (21.4) | −10.56 (21.4) | |
QTcF, msec | Former placebo patients | 407.8 (22.5) | −1.0 (14.4) |
Former GXR patients | 409.7 (17.0) | −5.0 (13.4) | |
New patients | 405.41 (19.8) | −1.21 (14.8) | |