Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry

BMC Psychiatry

Table 1 Top ten upregulated and downregulated proteins in MDD cerebrospinal fluid. Columns show UniProt ID, gene symbol, fold change, description, molecular function and cellular localization. Molecular function and cellular localization are from Ingenuity Pathway Analysis (IPA) software

Representative top molecules identified by IPA analysis in MDD patients
UniProt ID	Gene Symbol	Fold Change (MDD/Ctrl)	Description	Molecular Function	Cellular Localization
Upregulated Genes
O75460	ERN1	2.26	Ser/thr-protein kinase/endoribonuclease	Kinase	Cytoplasm
Q8IVL0	NAV3	1.96	Neuron navigator 3	Other	Nucleus
P0DOX6		1.88	Immunoglobulin mu heavy chain	Other	Other
Q969Y0	NXPE3	1.67	NXPE family member 3	Other	Other
P01009	SERPINA1	1.65	Alpha-1-antitrypsin	Other	Extracellular Space
P02679	FGG	1.65	Fibrinogen gamma chain	Other	Extracellular Space
P00746	CFD	1.64	Complement factor D	Peptidase	Extracellular Space
O75128	COBL	1.60	Protein cordon-bleu	Other	Plasma Membrane
P51884	LUM	1.59	Lumican	Other	Extracellular Space
P02675	FGB	1.56	Fibrinogen beta chain	Other	Extracellular Space
Downregulated Genes
P29622	SERPINA4	−2.07	Kallistatin	Other	Extracellular Space
P60174	TPI1	−1.96	Triosephosphate isomerase	Enzyme	Cytoplasm
O43293	DAPK3	−1.65	Death-associated protein kinase 3	Kinase	Cytoplasm
A0A075B6K4	IGLV3–10	−1.65	Immunoglobulin lambda variable 3–10	Other	Other
P04090	RLN2	−1.55	Prorelaxin H2	Other	Extracellular Space
P0C0L5	C4A/C4B	−1.50	Complement C4-B	Other	Extracellular Space
Q8IVW6	ARID3B	−1.49	AT-rich interactive domaincontaining protein 3B	Transcription Regulator	Nucleus
Q6P1S2	C3orf33	−1.45	Protein C3orf33	Other	Extracellular Space
P25705	ATP5F1A	−1.40	ATP synthase subunit alpha, mitochondrial	Transporter	Cytoplasm
P02765	AHSG	−1.39	Alpha-2-HS-glycoprotein	Other	Extracellular Space

ISSN: 1471-244X