Table 4 Upstream regulators with a predicted state of activation or inhibition. Based on the dataset, IPA generated a list of upstream regulators and determined their predicted activation state, activation z-score, and p-value of overlap with the dataset
From: Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry
Upstream Regulator | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|---|
IL6 | cytokine | Activated | 2.84 | 0.000000104 |
phenacetin | chemical drug | Activated | 2 | 0.00000104 |
carboplatin | chemical drug | Activated | 2 | 0.00000268 |
PRDM1 | transcription regulator | Activated | 2.433 | 0.0000037 |
thioacetamide | chemical toxicant | Activated | 2.388 | 0.00000558 |
STAT3 | transcription regulator | Activated | 2.24 | 0.00000969 |
OSM | cytokine | Activated | 2.594 | 0.000086 |
PPARGC1A | transcription regulator | Inhibited | −2.204 | 0.000384 |