Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach

BMC Psychiatry

Table 4 Characteristics of GWAS of Mendelian Randomization Analyses in Study Two

Phenotype	Study	Resource	N genome-wide significant SNPs^a	Total Sample size (N case, N control)	Population	Estimated SNP heritability	Data Source
Worry	Nagel et al. 2018 [29]	UK Biobank	60	348,219	European	9.1%	https://ctg.cncr.nl/software/summary_statistics
Depressed Affect	Nagel et al., 2018 [29]	UK Biobank	60	357,957	European	8.9%	https://ctg.cncr.nl/software/summary_statistics
Anxiety Disorder	Purves et al. 2019 [58]	UK Biobank, ANGST, iPSYCH	2	114,019 (31,977 cases, 82,114 controls)	European	Not reported	https://drive.google.com/drive/folders/1fguHvz7l2G45sbMI9h_veQun4aXNTy1v
Anorexia Nervosa	Watson et al. 2019 [28]	PGC	8	72,517 (16,992 cases 55,525 controls)	European	17.0%	https://www.med.unc.edu/pgc/results-and-downloads/ed./

ANGST Anxiety Neuro Genetics STudy; PGC Psychiatric Genetics Consortium
^a Independent genome-wide significant SNPs identified using LD threshold of R² < 0.001, and distance threshold of > 10,000 kb, based on 1000 genomes reference panel

ISSN: 1471-244X