Table 7 Thresholds and definitions for node states – Bayesian network for prediction of prolonged oral ketamine response
Variable | Definitions and thresholds for states | Discretisation method/ source |
|---|---|---|
Age | age_under_25 = < 25 years | determined by study authors |
age_25_44 = 25 ≤ years < 45 | ||
age_45_64 = 45 ≤ years < 65 | ||
age_65_up = ≥ 65 years | ||
Sex | male | determined by study authors |
female | ||
Tertiary education | yes = tertiary education | determined by study authors |
no = no tertiary education | ||
Employed | yes = employed; full time, part time or casual | determined by study authors |
no = unemployed or not in labour force | ||
Partnered | yes = married/de facto | determined by study authors |
no = never married, widowed, divorced, separated | ||
Suicide attempts | none = no previous suicide attempt | determined by study authors |
one = one previous suicide attempt | ||
two_or_more = ≥ two previous suicide attempts | ||
BMI | underweight = <  18.5 | [58] |
healthy = 18.5–24.9 | ||
overweight = 25–29.9 | ||
obese = ≥ 30 | ||
Profile | low, high; latent variable (unobserved, parameterised during automated learning) | not applicable; latent variable |
MADRS | not_severe = ≤ 34 | [59] |
severe = > 34 | ||
SOFAS | low = <  55 | uniform widths |
high = ≥ 55 | ||
Prolonged response | yes = (i) ⩾50% improvement from pre-treatment BSS at the end of the post-treatment follow-up phase, or (ii) BSS score ≤ 6 at the end of the post-treatment follow-up phase no = no improvement as defined for ‘yes’ | determined by study authors |