CYP2D6 phenotype | UM | EM | IM | PM |
---|---|---|---|---|
Placebo |  | −8.5 ± 8.4 (43) | − 6.1 ± 11.1 (9) |  |
TS-141 30 mg |  | − 5.5 ± 7.0 (44) | − 5.6 ± 5.6 (9) | − 23.0 (1) |
TS-141 60 mg | − 6.0 (1) | − 5.5 ± 6.9 (39) | − 3.9 ± 5.0 (10) |  |
TS-141120 mg | − 2.0 ± 4.2 (2) | − 7.6 ± 7.1 (40) | − 11.2 ± 9.5 (11) |  |