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Table 5 Mean changes in ADHD RS-IV-J:I by CYP2D6 phenotype in the subgroup analysis (FAS)

From: Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder

CYP2D6 phenotype

UM

EM

IM

PM

Placebo

 

−8.5 ± 8.4 (43)

− 6.1 ± 11.1 (9)

 

TS-141 30 mg

 

− 5.5 ± 7.0 (44)

− 5.6 ± 5.6 (9)

− 23.0 (1)

TS-141 60 mg

− 6.0 (1)

− 5.5 ± 6.9 (39)

− 3.9 ± 5.0 (10)

 

TS-141120 mg

− 2.0 ± 4.2 (2)

− 7.6 ± 7.1 (40)

− 11.2 ± 9.5 (11)

 
  1. Mean ± SD (N)