Fig. 2

Modeled change scores by week. a HAM-D; 17-item Hamilton Depression Rating Scale (higher scores indicate greater depression; 0–8 no depression; 9–16 light; 17–24 moderate; ≥25 severe). Difference at 2 weeks in ITT p < 0.001; Error bars represent SD. b BDI-II; Becks Depression Inventar II (higher scores indicate greater depression; 0–12 no depression; 13–19 light; 20–28 moderate; ≥29 severe). Difference at 2 weeks in ITT p = 0.002; Error bars represent SD. c PSQI; The Pittsburgh Sleep Quality Index (higher scores indicate bad sleep, cutoff score of 5, < 5 good sleep, ≥5 bad sleep). Difference at 2 weeks in ITT p = 0.036; Error bars represent SD