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Table 2 Comparison of demographic and baseline clinical characteristics of patients with schizophrenia in the trial of switching to aripiprazole between rebound and no rebound in positive subscores (N = 63)

From: Abnormally low prolactin levels in schizophrenia patients after switching to aripiprazole in a randomized trial: a biomarker for rebound in psychotic symptoms?

Characteristic

Rebound in positive subscores (N = 21)

No rebound in positive subscores (N = 42)

Pa

Male, n (%)

9 (42.86)

17 (40.48)

0.86

Age, years, (SD)

41.8 (10.60)

37.1 (11.44)

0.14

Body height, cm, mean (SD)

161.5 (7.19)

162.7 (9.61)

0.70

Body weight, kg, mean (SD)

68.4 (11.35)

65.8 (12.29)

0.52

Age of onset, years, mean (SD)b

26.6 (9.04)

28.2 (8.75)

0.30

Early age of onset, n (%) b

2 (9.52)

6 (14.29)

0.71

Late dropout, n (%)

4 (19.05)

6 (14.29)

0.25

Prolactin level at baseline, ng/dL, mean (SD)

47.6 (69.48)

55.6 (57.63)

0.15

Positive subscore in PANSS at baseline, mean (SD)c

12.2 (4.41)

9.4 (4.26)

0.01*

Switching strategy in a previous trial, n (%)

  

0.72

 Fast strategy

10 (47.62)

22 (52.38)

 

 Slow strategy

11 (52.38)

20 (47.62)

 

Preswitching medication

  

0.04*

 First generation antipsychotics, n (%)

12 (57.14)

13 (30.95)

 

 Second generation antipsychotics, n (%)

9 (42.86)

29 (69.05)

 

 Chlorpromazine equivalent dose, mean (SD)

321.4 (198.20)

272.8 (247.60)

0.27

  1. *p < .05
  2. aFisher’s exact test (for categorical variables) or Mann-Whitney test (for continuous variables) in comparing the 2 groups
  3. bData missing for 1 patient
  4. cIncluding delusions (p1), hallucinations (p3), grandiosity (p5), suspiciousness (p6), and unusual thought content (g9)