TY - JOUR AU - Aprahamian, Ivan AU - Mamoni, Ronei Luciano AU - Cervigne, Nilva Karla AU - Augusto, Taize Machado AU - Romanini, Carla Vasconcelos AU - Petrella, Marina AU - da Costa, Daniele Lima AU - Lima, Natalia Almeida AU - Borges, Marcus K. AU - Oude Voshaar, Richard C. PY - 2020 DA - 2020/12/01 TI - Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression JO - BMC Psychiatry SP - 573 VL - 20 IS - 1 AB - To explore the mutual relationship between multimorbidity, mental illness and frailty, we have set-up the Multimorbidity and Mental health Cohort Study in FRAILty and Aging (MiMiCS-FRAIL) cohort. At the population level, multimorbidity, frailty and late-life depression are associated with similar adverse outcomes (i.e. falls, disability, hospitalization, death), share the same risk factors, and partly overlap in their clinical presentation. Moreover, these three variables may share a common underlying pathophysiological mechanism like immune-metabolic dysregulation. The overall objectives of MiMiCS-FRAIL are 1) to explore (determinants of) the cross-sectional and longitudinal relationship between multimorbidity, depression, and frailty among non-demented geriatric outpatients; 2) to evaluate molecular levels of senoinflammation as a broad pathophysiological process underlying these conditions; and 3) to examine adverse outcomes of multimorbidity, frailty and depression and their interconnectedness. SN - 1471-244X UR - https://doi.org/10.1186/s12888-020-02963-9 DO - 10.1186/s12888-020-02963-9 ID - Aprahamian2020 ER -