Table 5 Variables associated with low sTWEAK levels

Age (per year)

1.00 (0.98–1.03)

0.73

–

–

Diabetes duration (per year)

1.00 (0.98–1.02)

0.71

–

–

Sex (women)

1.5 (0.9–2.5)

0.14

–

–

Depression

6.5 (1.5–28.0)

0.012

7.1 (1.6–31.4)

0.009

High galectin-3 (≥2.6 ng/ml)

0.8 (0.4–1.6)

0.49

–

–

High HbA1c (> 70 mmol/mol (> 8.6%))

1.0 (0.6–1.8)

0.91

–

–

Total cholesterol (mmol/l)

1.2 (0.9–1.6)

0.19

–

–

LDL (mmol/l)

1.2 (0.9–1.7)

0.29

–

–

Triglycerides (mmol/l)

1.3 (0.9–2.0)

0.18

–

–

HDL (mmol/l)

0.8 (0.4–1.7)

0.60

–

–

Triglycerides/HDL-cholesterol ratio

1.5 (0.9–2.6)

0.11

–

–

S-Creatinine (μmol/l)

1.00 (0.98–1.01)

0.63

–

–

Abdominal obesity

1.4 (0.6–2.8)

0.42

–

–

BMI (per kg/m²)

0.7 (0.4–1.3)

0.26

–

–

Systolic BP (mm Hg)

1.01 (0.99–1.03)

0.33

–

–

Diastolic BP (mm Hg)

1.00 (0.96–1.03)

0.63

–

–

Hypoglycemia (severe episodes)

0.7 (0.2–2.6)

0.64

–

–

Smoking

1.0 (0.4–2.5)

0.92

–

–

Physical inactivity

2.1 (0.8–5.9)

0.14

–

–

Continuous subcutaneous insulin infusion

0.3 (0.1–0.7)

0.004

0.3 (0.1–0.6)

0.003

Antidepressants users

1.1 (0.4–3.0)

0.78

–

–

Lipid lowering drugs

1.2 (0.7–2.0)

0.56

–

–

Antihypertensive drugs

1.0 (0.6–1.8)

0.94

–

–

Cardiovascular complications

1.7 (0.4–8.3)

0.49

–

–