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Table 5 Variables associated with low sTWEAK levels

From: Low levels of soluble TWEAK, indicating on-going inflammation, were associated with depression in type 1 diabetes: a cross-sectional study

  Low sTWEAK (< 7.2 ng/ml)
  COR (95% CI) P - value AOR (95% CI) P - value 
Age (per year) 1.00 (0.98–1.03) 0.73
Diabetes duration (per year) 1.00 (0.98–1.02) 0.71
Sex (women) 1.5 (0.9–2.5) 0.14
Depression 6.5 (1.5–28.0) 0.012 7.1 (1.6–31.4) 0.009
High galectin-3 (≥2.6 ng/ml) 0.8 (0.4–1.6) 0.49
High HbA1c (> 70 mmol/mol (> 8.6%)) 1.0 (0.6–1.8) 0.91
Total cholesterol (mmol/l) 1.2 (0.9–1.6) 0.19
LDL (mmol/l) 1.2 (0.9–1.7) 0.29
Triglycerides (mmol/l) 1.3 (0.9–2.0) 0.18
HDL (mmol/l) 0.8 (0.4–1.7) 0.60
Triglycerides/HDL-cholesterol ratio 1.5 (0.9–2.6) 0.11
S-Creatinine (μmol/l) 1.00 (0.98–1.01) 0.63
Abdominal obesity 1.4 (0.6–2.8) 0.42
BMI (per kg/m2) 0.7 (0.4–1.3) 0.26
Systolic BP (mm Hg) 1.01 (0.99–1.03) 0.33
Diastolic BP (mm Hg) 1.00 (0.96–1.03) 0.63
Hypoglycemia (severe episodes) 0.7 (0.2–2.6) 0.64
Smoking 1.0 (0.4–2.5) 0.92
Physical inactivity 2.1 (0.8–5.9) 0.14
Continuous subcutaneous insulin infusion 0.3 (0.1–0.7) 0.004 0.3 (0.1–0.6) 0.003
Antidepressants users 1.1 (0.4–3.0) 0.78
Lipid lowering drugs 1.2 (0.7–2.0) 0.56
Antihypertensive drugs 1.0 (0.6–1.8) 0.94
Cardiovascular complications 1.7 (0.4–8.3) 0.49
  1. N = 278; Multiple logistic regression analyses (Backward: Wald); Nagelkerke R Square: 0.094; Hosmer and Lemeshow test 0.802