Identifying response and predictive biomarkers for Transcranial magnetic stimulation outcomes: protocol and rationale for a mechanistic study of functional neuroimaging and behavioral biomarkers in veterans with Pharmacoresistant depression

Table 4 Data Collection Summary for Primary and Secondary Outcome Measures

	Baseline	1 Week	Post-treatment
Outcome Measures
Primary Outcomes - Neuroimaging (Aim 1)
Functional MRI
GoNoGo Task	X	X	X
N-Back Working Memory Task	X	X	X
Resting State	X	X	X
Structural MRI
T1 Anatomical	X		X
Secondary Outcomes - Cognitive-Behavioral Measures (Aim 2)
CNS Vital Signs Battery (SDC, Stroop, SAT, CPT Subtests)	X	X	X
Webneuro Abbreviated Version (GoNoGo and N-Back Subtests)	X	X	X
Secondary Outcomes - Clinical Outcome Measures (Aim 3)
Quick Inventory of Depressive Symptoms (QIDS)- Self Report Form	X	X	X
Veterans’ RAND 36-item Health Survey (VR-36)	X	X	X
Columbia-Suicide Severity Rating Scale (C-SSRS)	X	X	X

Data collection occurs at 4 time points as shown above. Enrollment and Baseline research sessions occur prior to the commencement of TMS treatment session 1. The 1 Week research session occurs after completion of the first TMS treatment sessions within the first week, targeting the first 5 TMS sessions. The Post-treatment research session occurs after completion of TMS treatment, targeting 30 TMS sessions

ISSN: 1471-244X