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Table 1 Demographic characteristics and genotypes of the study population

From: Effect of CYP2D6 polymorphisms on plasma concentration and therapeutic effect of risperidone

 

Total study population (n = 76)

Sex (male/female)

38/38

Age (years)

45.0 (33.0, 54.0)

Height (cm)

164.5 (158.0, 171.0)

Weight (kg)

65.5 (56.3, 74.5)

BMI

23.3 (21.4, 27.9)

Dose (mg)

5.0 (4.0, 6.0)

PANSS

88.0 (82.0, 95.0)

BPRS

45.5 (41.3, 50.8)

CGI-S (2 week)

5.0 (5.0, 6.0)

CGS-I (2 week)

3.0 (3.0, 4.0)

Mutation sites

 100 (C > T)

62 (81.6)

 1038 (C > T)

62 (81.6)

 1662 (G > C)

68 (89.5)

 2851 (C > T)

20 (26.3)

 4181 (G > C)

71 (93.4)

Genotypes

 CYP2D6*10

47 (81.6)

 CYP2D6*2

7 (9.2)

 CYP2D6*65

13 (17.1)

  1. Data are presented as median (interquartile range) or number (%)
  2. Abbreviation: BMI Body mass index, PANSS Positive and Negative Syndrome Scale, BPRS Brief Psychiatric Rating Scale, CGI-S Clinical Global Impression-Severity, CGI-I Clinical Global Impression-Improvement