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Table 1 Baseline characteristics of preconception women and pregnant women with high decisional conflict. Categorical variables presented as n (%) and compared using chi-squared (x2) tests, and continuous variables presented as mean ± standard deviation (SD) and compared using independent t-tests

From: Decision-making about antidepressant medication use in pregnancy: a comparison between women making the decision in the preconception period versus in pregnancy

Variable

Preconception

(n = 55)

Pregnant

(n = 40)

Test statistic;

P-value

Recruitment Site (Online), n (%)

30 (54.5)

15 (37.5)

x2 = 2.70; p = 0.10

Demographics and Health History

 Age in years, Mean ± SD

33.3 ± 4.29

33.9 ± 4.15

t = 0.68; p = 0.50

 Married or cohabitating with partner, n (%)

51 (92.7)

36 (90.0)

x2 = 0.22; p = 0.64

 Completed a university degree, n (%)

52 (94.5)

39 (97.5)

x2 = 0.50; p = 0.48

 Annual household income (CAD/year), n (%)

  

x2 = 4.22; p = 0.38

   < 40,000

2 (3.6)

5 (12.5)

 

  40,000-80,000

16 (29.1)

13 (32.5)

 

   > 80,000

36 (65.5)

22 (55.0)

 

  Preferred not to answer

1 (1.1)

0 (0)

 

 Canadian-born, n (%)

49 (89.1)

33 (82.5)

x2 = 2.14; p = 0.34

 Nulliparous, n (%)

37 (67.3)

23 (57.5)

x2 = 0.95; p = 0.33

 Current smoker, n (%)

4 (7.3)

3 (7.5)

x2 = 0.002; p = 0.97

 Other medical condition, n (%)

20 (37.0)

14 (35.0)

x2 = 0.04; p = 0.84

Psychiatric History

 Lifetime antidepressant use, n (%)

55 (100.0)

36 (90.0)

x2 = 4.37; p = 0.04

 Prior response to antidepressants, n (%)a

  

x2 = 5.62; p = 0.06

  No effect

1 (1.8)

5 (14.3)

 

  Moderate effect

15 (27.3)

10 (28.6)

 

  Beneficial effect

39 (70.9)

20 (57.1)

 

 Prior adverse effects from antidepressants, n (%)a

21 (38.2)

16 (45.7)

x2 = 0.50; p = 0.48

 Lifetime psychiatric hospitalization, n (%)

3 (5.5)

6 (15.0)

x2 = 2.46; p = 0.12

Current mental health treatmentb

 Antidepressant medication, n (%)

47 (85.5)

18 (45.0)

x2 = 17.5; p < 0.001

 Individual therapy, n (%)

20 (36.4)

17 (42.5)

x2 = 0.37; p = 0.55

 Group therapy, n (%)

2 (3.6)

1 (2.5)

x2 = 0.10; p = 0.76

 Psychiatrist, n (%)

16 (29.1)

21 (52.5)

x2 = 5.34; p = 0.01

 Family doctor, n (%)

30 (54.5)

17 (42.5)

x2 = 1.34; p = 0.25

 Social worker, n (%)

3 (5.5)

4 (10.0)

x2 = 0.70; p = 0.40

 Psychologist, n (%)

11 (20.0)

4 (10.0)

x2 = 1.74; p = 0.19

Scales

 Edinburgh Postnatal Depression Scale, Mean ± SD

11.5 ± 4.76

13.4 ± 5.42

t = 1.85; p = 0.07

 High Edinburgh Postnatal Depression Scale (≥13), n(%)

22 (40.0)

26 (65.0)

x2 = 5.79; p = 0.02

 State-Trait Anxiety Inventory (Trait), Mean ± SD

50.0 ± 10.8

48.9 ± 10.5

t = −0.47; p = 0.64

 High State-Trait Anxiety Inventory (Trait) (≥40), n(%)

45 (81.8)

32 (80.0)

x2 = 0.05; p = 0.82

 State-Trait Anxiety Inventory (State), Mean ± SD

42.3 ± 12.2

46.3 ± 14.0

t = 1.49; p = 0.14

 High State-Trait Anxiety Inventory (State) (≥40), n(%)

26 (47.3)

22 (55.0)

x2 = 0.55; p = 0.46

 Decisional Conflict Scale, Mean ± SD

49.3 ± 14.2

42.5 ± 50.0

t = −2.27; p = 0.03

 High Decisional Conflict Scale (≥37.5), n(%)

46 (83.6)

24 (60.0)

x2 = 6.67; p = 0.01

 Knowledge Score, Mean ± SD

12.0 ± 1.50

12.1 ± 1.90

t = 0.34; p = 0.74

  1. aPercentage of those who had used antidepressive agents. Note that prior benefit/side effects is missing for one pregnant participant
  2. bThese categories are not mutually exclusive