Table 2 Characteristics of women who intend to use antidepressant medication in pregnancy (n = 46) and those who do not intend to use antidepressant medication in pregnancy (n = 49). Categorical variables presented as n (%) and compared using chi-squared (x2) tests, and continuous variables presented as mean ± standard deviation (SD) and compared using independent t-tests
Variable | Intends to use antidepressant in pregnancy (n = 46) | Intends to not use antidepressant in pregnancy (n = 49) | Test statistic; P-value |
|---|---|---|---|
Demographics and Health History | |||
 Age in years, Mean ± SD | 33.6 ± 4.3 | 33.6 ± 4.2 | t = 0.02; p = 0.99 |
 Married or cohabitating with partner, n (%) | 45 (97.8) | 42 (85.7) | x2 = 4.51; p = 0.03 |
 Completed a university degree, n (%) | 43 (93.5) | 48 (98.0) | x2 = 1.18; p = 0.28 |
 Annual household income (CAD/year), n (%) |  |  | x2 = 6.19; p = 0.18 |
   < 40,000 | 1 (2.2) | 6 (12.3) |  |
  40,000-80,000 | 12 (26.1) | 17 (34.7) |  |
   > 80,000 | 32 (69.6) | 26 (53.1) |  |
  Preferred not to answer | 1 (2.2) | 0 (0.0) |  |
 Canadian-born, n (%) | 40 (87.0) | 42 (85.7) | x2 = 1.29; p = 0.52 |
 Nulliparous, n (%) | 29 (63.0) | 31 (63.3) | x2 = 0.001; p = 0.98 |
 Current smoker, n (%) | 3 (6.5) | 4 (8.2) | x2 = 0.09; p = 0.76 |
 Other medical condition, n (%) | 12 (26.7) | 22 (44.9) | x2 = 3.38; p = 0.07 |
Psychiatric History | |||
 Lifetime antidepressant use, n (%) | 44 (95.7) | 47 (97.9) | x2 = 0. 39; p = 0.53 |
 Prior response to antidepressants, n (%)a |  |  | x2 = 4.46; p = 0.11 |
  No effect | 1 (2.2) | 5 (10.9) |  |
  Moderate effect | 10 (21.7) | 15 (32.6) |  |
  Beneficial effect | 33 (71.7) | 26 (56.5) |  |
 Prior adverse effects from antidepressants, n(%)a | 18 (40.9) | 19 (41.3) | x2 = 0.001; p = 0.97 |
 Lifetime psychiatric hospitalization, n (%) | 5 (10.9) | 4 (8.2) | x2 = 0.20; p = 0.65 |
Current mental health treatmentb | |||
 Antidepressant medication, n (%) | 42 (91.3) | 23 (46.9) | x2 = 21.6; p < .001 |
 Individual therapy, n (%) | 15 (32.6) | 22 (44.9) | x2 = 1.51; p = 0.22 |
 Group therapy, n (%) | 2 (4.3) | 1 (2.0) | x2 = 0.41; p = 0.52 |
 Psychiatrist, n (%) | 16 (34.8) | 21 (42.9) | x2 = 0.65; p = 0.42 |
 Family doctor, n (%) | 29 (63.0) | 18 (36.7) | x2 = 10.2; p < 0.01 |
 Social worker, n (%) | 1 (2.2) | 6 (12.2) | x2 = 3.38; p = 0.07 |
 Psychologist, n (%) | 6 (13.0) | 9 (18.4) | x2 = 0.41; p = 0.52 |
Scales | |||
 Edinburgh Postnatal Depression Scale, Mean ± SD | 11.1 ± 5.6 | 13.4 ± 4.3 | t = −2.28; p = 0.02 |
 High Edinburgh Postnatal Depression Scale (≥13), n(%) | 20 (43.5) | 28 (57.1) | x2 = 1.77; p = 0.18 |
 State-Trait Anxiety Inventory (Trait), Mean ± SD | 48.4 ± 12.0 | 50.5 ± 9.2 | t = −0.95; p = 0.34 |
 High State-Trait Anxiety Inventory (Trait) (≥40), n(%) | 35 (76.1) | 42 (85.7) | x2 = 1.43; p = 0.23 |
 State-Trait Anxiety Inventory (State), Mean ± SD | 41.9 ± 13.2 | 45.9 ± 12.8 | t = −1.47; p = 0.15 |
 High State-Trait Anxiety Inventory (State) (≥40), n(%) | 18 (39.1) | 30 (61.2) | x2 = 4.63; p = 0.03 |
 Decisional Conflict Scale, Mean ± SD | 43.7 ± 15.6 | 49.0 ± 13.6 | t = − 1.74; p = 0.08 |
 High Decisional Conflict Scale (≥37.5), n (%) | 29 (63.0) | 41 (83.7) | x2 = 5.21; p = 0.02 |
 Knowledge Score, Mean ± SD | 64.8 ± 8.4 | 64.6 ± 9.8 | t = 0.43; p = 0.67 |