Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study

Table 3 Comparisons among working memory test by diagnostic, genotypic groups and interaction analysis for promoter variant

Test	Diagnosis		Genotype		Diagnosis x genotype		Genotype x expression		Diagnosis x genotype x expression		Statistical Power	Effect size F
Test	F	p	F	p	F	p	F	p	F	p	Statistical Power	Effect size F
WMI	9.44	0.003*	0.104	0.748	6.11	0.015	1.17	0.281	1.32	0.253	0.975	0.906
Arithmetic	12.257	0.001*	0.166	0.685	2.59	0.110	1.19	0.276	0.609	0.437	0.947	0.852
DS	5.26	0.024	2.86	0.093	3.25	0.074	2.57	0.111	0.673	0.413	0.702	0.668
BDS task	5.01	0.027	7.48	0.007*	6.20	0.014	7.14	0.009*	1.719	0.192	0.772	0.706
LNS	4.03	0.047	0.028	0.868	8.89	0.003^*	0.796	0.374	2.13	0.147	0.732	0.684

Two-way ANCOVA analysis was performed for each cognitive analysis. The two fixed factors were the genotype (recessive model) and the diagnosis (schizophrenia vs control). The expression levels NR4A2 was used as a covariant, as well as demographic data including age, sex, and education level. The interaction of diagnosis x genotype, genotype x expression and diagnosis x genotype x expression were obtained
The WMI and its three subtests (DS, Arithmetic, and LNS) that compose it were analyzed. The BDS task that is part of DS subtest was also considered for analysis. This is a subset of the total sample submitted to cognition tasks with 53 case and 82 controls, which had genotyping and quantification of NR42 expression levels
WMI Working memory index, DS Total Digit Span, BDS Backward Digit Span, LNS Letter-Number Sequencing, F Test statistic for ANCOVA, p p-value
* Bonferroni correction < 0.01

ISSN: 1471-244X