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Table 1 Conditional power

From: Conditional power of antidepressant network meta-analysis

    

NCP=20%

NCP=80%

    

Sample size

Sample size

 

Trial design

Effect size

Event probability

median [range]

median [range]

Efficacy

Main analysis

r = 1/0

fxyN

pcN = 0.17

250 [49 - 485]

1586 [894 - 4190]

Sensitivity analysis

r = 1/1

fxyN

pcN = 0.17

126 [10 - 384]

1198 [720 - 3464]

 

r = 1/2

fxyN

pcN = 0.17

117 [10 - 222]

994 [624 - 2586]

 

r = 1/0

fxy d = 0.01

pcN = 0.17

250 [49 - 483]

1576 [916 - 4176]

 

r = 1/0

fxy d = 0.1

pcN = 0.17

245 [49 - 509]

1612 [866 - 4371]

 

r = 1/0

fxy d = 0.2

pcN = 0.17

242 [49 - 538]

1644 [817 - 4682]

 

r = 1/0

fxy d = 0.3

pcN = 0.17

238 [49 - 566]

1628 [773 - 9660]

 

r = 1/0

fxy d = 0.5

pcN = 0.17

236 [47 - 622]

1668 [695 - 9772]

 

r = 1/0

fxy d = 0.8

pcN = 0.17

228 [44 - 699]

1754 [595 - 9880]

 

r = 1/0

fxyN

pc = 0.01

706 [51 - 1407]

3678 [2471 - 10000]

 

r = 1/0

fxyN

pc = 0.1

373 [50 - 741]

2384 [1370 - 9927]

 

r = 1/0

fxyN

pc = 0.2

212 [48 - 416]

1367 [781 - 3793]

 

r = 1/0

fxyN

pc = 0.3

136 [43 - 318]

1044 [599 - 3217]

 

r = 1/0

fxyN

pc = 0.5

96 [36 - 271]

874 [503 - 2877]

Tolerability

Main analysis

r = 1/0

fxyN

pcN = 0.57

198 [40 - 320]

791 [521 - 1246]

Sensitivity analysis

r = 1/1

fxyN

pcN = 0.57

104 [64 - 278]

738 [414 - 1258]

 

r = 1/2

fxyN

pcN = 0.57

102 [81 - 168]

675 [480 - 1161]

 

r = 1/0

fxy d = 0.01

pcN = 0.57

207 [41 - 318]

766 [619 - 1202]

 

r = 1/0

fxy d = 0.1

pcN = 0.57

192 [40 - 321]

782 [569 - 1283]

 

r = 1/0

fxy d = 0.2

pcN = 0.57

181 [40 - 343]

791 [513 - 1373]

 

r = 1/0

fxy d = 0.3

pcN = 0.57

170 [39 - 366]

817 [471 - 1462]

 

r = 1/0

fxy d = 0.5

pcN = 0.57

146 [39 - 420]

908 [409 - 1782]

 

r = 1/0

fxy d = 0.8

pcN = 0.57

121 [40 - 615]

1027 [320 - 2497]

 

r = 1/0

fxyN

pc = 0.01

319 [41 - 523]

1258 [824 - 1991]

 

r = 1/0

fxyN

pc = 0.1

153 [41 - 277]

662 [442 - 1046]

 

r = 1/0

fxyN

pc = 0.2

55 [37 - 117]

371 [257 - 582]

 

r = 1/0

fxyN

pc = 0.3

40 [32 - 72]

277 [207 - 435]

 

r = 1/0

fxyN

pc = 0.5

34 [31 - 55]

227 [192 - 365]

  1. Listed are median [range] of sample sizes at 20% and 80% conditional power (NCP=20%, NCP=80%) with respect to the three parameters considered in the sensitivity analysis, i.e., trial design (r), effect size (fxy), and event probability. The first row for each outcome lists results obtained in the main analysis considering a trial design with a ratio of direct/indirect evidence of r = 1/0, with anticipated effect sizes set equal to the network estimates (fxyN), and anticipated event probabilities set equal to the average network event probabilities (pcN). The remaining rows list results obtained in the sensitivity analyses considering trial designs with ratios of direct/indirect evidence of r = 1/1 and r = 1/2, varying anticipated effect sizes (fxy in terms of Cohen’s d), and varying anticipated event probabilities (pc). The supplementary appendix provides details on sensitivity analyses (Supplement 1, Fig. S3, Tab. S3)