Factors related to age at depression onset: the role of SLC6A4 methylation, sex, exposure to stressful life events and personality in a sample of inpatients suffering from major depression

Table 4 Partial Spearman’s correlation coefficients (below the diagonal) and p-values (above the diagonal for the whole sample and both sexes separately

whole sample (N = 146)	BDI-II	MADRS	CLEQ	SEEKING	SADNESS	age at onset	SLC6A4 factor 1	SLC6A4 factor 2
BDI-II		< 0.001	< 0.001	< 0.001	< 0.001	0.025	0.700	0.700
MADRS	0.62***		0.035	< 0.001	< 0.001	0.160	0.700	0.123
CLEQ	0.33***	0.21*		0.700	0.011	0.001	0.869	0.598
SEEKING	−0.32***	− 0.32***	0.05		0.008	0.102	0.998	0.416
SADNESS	0.49***	0.42***	0.25*	−0.26**		< 0.001	0.998	0.755
age at onset	−0.22*	−0.14	− 0.31**	0.17	−0.35***		0.220	0.700
SLC6A4 factor 1	0.06	0.05	0.02	−0.00	− 0.00	− 0.14		0.372
SLC6A4 factor 2	−0.05	0.17	−0.08	0.10	0.04	0.05	− 0.11
women (n = 95)
BDI-II		< 0.001	0.065	0.006	< 0.001	0.437	0.479	0.998
MADRS	0.66***		0.562	0.012	< 0.001	0.851	0.851	0.026
CLEQ	0.25	0.10		0.826	0.769	0.042	0.361	0.479
SEEKING	−0.36**	− 0.33*	0.05		0.026	0.361	0.945	0.479
SADNESS	0.47***	0.47***	0.07	−0.30**		0.049	0.479	0.785
age at onset	−0.14	−0.04	− 0.27*	0.16	−0.26*		0.769	0.907
SLC6A4 factor 1	−0.13	−0.04	− 0.17	0.01	−0.13	0.07		0.945
SLC6A4 factor 2	−0.00	0.31*	−0.12	0.13	0.06	0.03	− 0.02
men (n = 51)
BDI-II		< 0.001	0.014	0.180	0.006	0.181	0.829	0.956
MADRS	0.61***		0.011	0.124	0.047	0.047	0.956	0.956
CLEQ	0.45*	0.46*		0.975	0.001	0.026	0.401	0.956
SEEKING	−0.27	− 0.30	0.00		0.578	0.101	0.962	0.956
SADNESS	0.50**	0.36*	0.56**	−0.15		0.014	0.956	0.703
age at onset	−0.26	−0.36*	− 0.40*	0.32	−0.43*		0.233	0.956
SLC6A4 factor 1	0.09	0.05	0.20	−0.02	−0.05	− 0.25		0.616
SLC6A4 factor 2	−0.02	−0.02	0.06	0.04	0.12	− 0.03	−0.14

Covariates: age and BMI. FDR corrected p-values (for each sample separately). *** p < .001, ** p < .01, * p < .05

ISSN: 1471-244X