An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt

BMC Psychiatry

Table 2 Estimated SNP heritability of psychiatric traits, personality and sociodemographic factors in ALSPAC using restricted maximum likelihood analysis and linkage disequilibrium score regression

Trait	n	% cases	h²_SNP	SE	Log likelihood
	Estimates from REML
Non-suicidal self-harm (main outcome)	4506	17.31	0.13	0.07	2174
Suicide attempt (main outcome)	4506	9.25	0.00	0.07	3345
ADHD	6440	3.14	0.01	0.05	8050
Alcohol consumption	3487		0.18	0.09	− 5760
Anorexia	5624	1.03	0.00	0.06	10,064
Anxiety	6644	15.12	0.04	0.05	3548
ASC	7794	2.56	0.00	0.04	10,434
Cannabis problematic use	1909	1.78	0.00	0.16	2891
Conscientiousness	4121		0.15	0.08	− 9272
Depression	6742	31.50	0.01	0.05	1940
Education	4007	49.45	0.38	0.08	784
Extraversion	4311		0.10	0.08	−10,407
Income	2929		0.00	0.11	− 1397
IQ	5672		0.37	0.06	−17,900
Neuroticism	4184		0.03	0.08	− 9818
Agreeableness	4239		0.14	0.08	− 8802
Schizophrenia	2744	< 0.50%	0.14	0.12	9446
Openness	4223		0.23	0.08	− 9360
Suicide attempt (by age 26)	4739	10.49	0.06	0.07	3249
	Estimates from LDSC
NSSH	4518	17.31	0.008	0.096
SA (age 24)	4518	9.25	−0.109	0.098
SA (age 26)	4518	10.49	− 0.109	0.098

REML restricted maximum likelihood analysis, LDSC linkage disequilibrium score regression, h²_SNP SNP-based heritability, SE standard error, ADHD attention deficit/hyperactivity disorder, ASC autism spectrum conditions, NSSH non-suicidal self-harm, SA suicide attempt

ISSN: 1471-244X