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Table 3 Multinomial Poisson logistic regression results (n = 4959) showing association between polygenic risk score for 17 related phenotypes with non-suicidal self-harm and suicide attempt

From: An exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt

 

Non-suicidal self-harm

Suicide attempt

Exposure

RR

95% CI

RR

95% CI

ADHD

1.10

1.02, 1.19

1.21

1.09, 1.34

Alcohol

1.07

0.98, 1.16

0.99

0.89, 1.10

Anorexia

1.01

0.93, 1.09

1.12

1.01, 1.23

Anxiety

0.98

0.90, 1.05

0.96

0.87, 1.06

ASC

1.09

1.01, 1.18

1.09

0.98, 1.20

Cannabis

1.03

0.95, 1.11

0.99

0.89, 1.09

Conscientiousness

1.02

0.94, 1.10

1.00

0.90, 1.11

Depression

1.17

1.08, 1.27

1.47

1.32, 1.63

Education

1.04

0.96, 1.12

0.97

0.88, 1.07

Extraversion

0.98

0.91, 1.06

0.97

0.88, 1.08

Income

1.01

0.93, 1.09

0.90

0.81, 0.99

IQ

1.14

1.06, 1.24

1.02

0.92, 1.13

Neuroticism

1.16

1.08, 1.26

1.27

1.14, 1.40

Agreeableness

0.94

0.87, 1.02

0.93

0.84, 1.03

Schizophrenia

1.05

0.97, 1.14

1.06

0.96, 1.17

Openness

1.01

0.93, 1.09

1.02

0.92, 1.13

Suicide attempt

1.07

0.99, 1.15

1.10

0.99, 1.21

  1. Reference category: no self-harm. Polygenic scores standardised to have mean 0 and standard deviation 1 so the RR represents the change in risk of the outcome per 1 standard deviation increase in polygenic risk score
  2. ADHD attention deficit/hyperactivity disorder, ASC autism spectrum conditions
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BMC Psychiatry

ISSN: 1471-244X

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