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Table 12 Odds Ratios for Somnolence and Switch to Mania

From: Efficacy and tolerability of atypical antipsychotics for acute bipolar depression: a network meta-analysis

PLO 2.04 [0.98, 3.79] 1.90 [0.81, 4.05] 2.89 [1.96, 4.20] 4.90 [3.59, 6.56] 5.05 [2.61, 9.25] 1.53 [0.57, 3.66]
2.25 [0.81, 5.19] ARI 1.04 [0.32, 2.61] 1.59 [0.68, 3.16] 2.70 [1.21, 5.31] 2.79 [0.98, 6.44] 0.84 [0.24, 2.28]
0.91 [0.41, 1.71] 0.50 [0.13, 1.33] CAR 1.79 [0.64, 3.85] 3.03 [1.13, 6.47] 3.12 [0.99, 7.67] 0.93 [0.23, 2.52]
0.79 [0.28, 1.67] 0.44 [0.09, 1.22] 0.99 [0.26, 2.58] OLA 1.76 [1.06, 2.75] 1.81 [0.81, 3.57] 0.55 [0.18, 1.40]
0.61 [0.35, 0.99] 0.34 [0.10, 0.83] 0.77 [0.29, 1.69] 0.95 [0.30, 2.46] QUE 1.05 [0.50, 2.00] 0.32 [0.11, 0.80]
NA NA NA NA NA ZIP 0.33 [0.09, 0.87]
2.36 [0.39, 8.83] 1.31 [0.14, 5.39] 2.96 [0.39, 11.82] 3.74 [0.43, 15.93] 4.17 [0.61, 16.11] NA LUR
  1. Note: Somnolence results are on the top-right and Switch to Mania results are on the bottom-left. Numbers represent the odds ratio [95% credible interval]. In the top-right comparisons, the row treatment is the reference category
  2. Abbreviations: PLO Placebo, ARI Aripiprazole, CAR Cariprazine, LUR Lurasidone, OLA Olanzapine, QUE Quetiapine, ZIP Ziprasidone