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Table 12 Odds Ratios for Somnolence and Switch to Mania

From: Efficacy and tolerability of atypical antipsychotics for acute bipolar depression: a network meta-analysis

PLO

2.04 [0.98, 3.79]

1.90 [0.81, 4.05]

2.89 [1.96, 4.20]

4.90 [3.59, 6.56]

5.05 [2.61, 9.25]

1.53 [0.57, 3.66]

2.25 [0.81, 5.19]

ARI

1.04 [0.32, 2.61]

1.59 [0.68, 3.16]

2.70 [1.21, 5.31]

2.79 [0.98, 6.44]

0.84 [0.24, 2.28]

0.91 [0.41, 1.71]

0.50 [0.13, 1.33]

CAR

1.79 [0.64, 3.85]

3.03 [1.13, 6.47]

3.12 [0.99, 7.67]

0.93 [0.23, 2.52]

0.79 [0.28, 1.67]

0.44 [0.09, 1.22]

0.99 [0.26, 2.58]

OLA

1.76 [1.06, 2.75]

1.81 [0.81, 3.57]

0.55 [0.18, 1.40]

0.61 [0.35, 0.99]

0.34 [0.10, 0.83]

0.77 [0.29, 1.69]

0.95 [0.30, 2.46]

QUE

1.05 [0.50, 2.00]

0.32 [0.11, 0.80]

NA

NA

NA

NA

NA

ZIP

0.33 [0.09, 0.87]

2.36 [0.39, 8.83]

1.31 [0.14, 5.39]

2.96 [0.39, 11.82]

3.74 [0.43, 15.93]

4.17 [0.61, 16.11]

NA

LUR

  1. Note: Somnolence results are on the top-right and Switch to Mania results are on the bottom-left. Numbers represent the odds ratio [95% credible interval]. In the top-right comparisons, the row treatment is the reference category
  2. Abbreviations: PLO Placebo, ARI Aripiprazole, CAR Cariprazine, LUR Lurasidone, OLA Olanzapine, QUE Quetiapine, ZIP Ziprasidone