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Table 1 Demographic and clinical characteristics of the AUD participants in the study in the meta-analysis

From: Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis

Study AUD patients      Healthy controls   Methodology   
No. (male) Mean age, yr Diagnosis Diagnosis criteria Abstinence or not (abstinence duration) No. (male) Mean age, yr MRI scanner Smooth kernel Volume or density Corrected level
Jang et al. (2007) 20 (20) 43.6 (6) Alcohol-dependence DSM-IV Yes (7.8 days)2 20 (20) 44.5 (7.4) 3.0 T 8 density FDR, p < 0.05
Mechtcheriakov et al.(2007) 22 (14) 53.6 Alcohol addiction ICD-10 Yes (10 days)2 22 (14) 53.7 1.5 T 10 volume FDR, p < 0.05
Chanraud et al. (2007) 26 (26) 47.7 (7.1) Alcohol-dependence DSM-IV Yes (3 weeks)2 24 (24) 45 (6.7) 1.5 T 8 volume FDR p < 0.005
Chanraud et al. (2009) 24 (24) 47.8 (7.7) Alcohol-dependence DSM-IV Yes (3 weeks)2 24 (24) 45 (5.6) 1.5 T Ns volume Not mention
Demirakca et al. (2011) 50 (27) 45 (10.1) Alcohol-dependence DSM-IV &ICD-10 Yes(16.5 days)2 66 (34) 44.1 (10.3) 1.5 T 8 volume FWE, p < 0.05
Rando et al.(2011) 55(35) 38.2 alcohol-dependent DSM-IV Yes(1 month)1 50(28) 31.14 Ns 8 volume FWE,p < 0.025
Grodin et al.(2012) 37(21) 40.2(9.2) alcoholics DSM-IV Yes(21.5 days)2 69(47) 36.6(1.1) 1.5 T 3 volume p < 0.01
van Holst et al. (2012) 36 (36) 43.2 (11.03) AUD DSM-IV-TR Yes (18 days)2 54 (54) 35.3 (10.1) 3.0 T 8 volume FDR, p < 0.05
Howell et al. (2013) 19 (7) 22.95 (3.41) Alcohol Abuse AADC Yes (24 h)2 19 (7) 24.63 (4.40) 3.0 T 10 volume K = 19, p < 0.05
Charlet et al.(2014) 40(30) 44.9(11.4) alcohol-dependent DSM-IV Yes(11.4 days)2 40(30) 44.1(12.0) 3.0 T 8 volume FWE,p < 0.05
Asensio et al.(2015) 24(24) 35.62(4.81) alcohol abuse DSM-IV Yes (3 days)2 24(24) 31.91(9.3) 1.5 T 8 volume p < 0.05
Padula et al.(2015) 14(6) 43.21 (9.13) Alcohol-dependent DSM-IV Yes (1 month)2 14(5) 37.57 (12.08) 3.0 10 volume Not mention
Romanczuk-Seiferth(2015) 15(15) 45.40 (10.15) alcohol-dependent ICD-10&DSM-IV Yes(42 days)2 17(17) 37.41 (11.76) Ns 8 volume Not mention
Wiers et al.(2015) 22(22) 42.14(6.20) alcohol dependence DSM-IV Yes(48 days)2 21(21) 41.95(6.4) 3.0 T 10 volume FWE,p < 0.005
Wang et al.(2016) 20(20) 43.95(8.17) alcohol dependence DSM-IV Yes (1 month)2 20(20) 40.5(6.30) 3.0 T 8 volume FWE,P < 0.05
Guggenmos et al.(2017) 119(101) 45(10.7) AD DSM-IV-TR&ICD-10 Yes(22.8 days)2 97(81) 43.7(10.8) 3.0 T 8 volume FWE, p < 0.05
Bach et al.(2017) 74(55) 46.55(10.02) alcohol-dependent DSM Yes(2.5 days)2 43(27) 46.49(9.2) 3.0 T 8 volume FWE,p < 0.05
Zois et al.(2017) 95(71) 45.9(9.9) AD DSM-IV Yes(11.7 days)2 87(71) 45.9(10.6) 3.0 T 8 volume FWE,p < 0.05
Wu et al.(2018) 9(5) 47(11.2) alcohol-dependent Not mention Yes(14 days)2 22(13) 44.9(9.5) 3.0 T 8 volume FWE,p < 0.05
Wang et al.(2018) 21(21) 45.95 (7.07) alcohol dependence DSM-IV Yes(50.58 days)2 33(33) 42.88 (6.05) 3.0 T 8 volume FWE,p < 0.05
Li et al.(2019) 20(17) 49(12) alcohol addiction ICD-10 Not mention 20(17) 49(12) 3.0 T 8 volume Not mention
Bach et al.(2020) 62(48) 25.8(4.4) alcohol-dependent DSM-IV Yes(11.77 days)2 74(58) 44.12(9.6) 3.0 T 15 volume FWE,p < 0.05
Galandra et al.(2020) 22(13) 45.59 (7.99) Alcohol Use Disorder DSM-V Yes(28 days)2 18(10) 44.83 (8.86) 3.0 T 8 density FWE,p < 0.05
  1. Note: AADC, National Institute on Alcoholism and Alcohol Abuse diagnostic criteria; AUD, alcohol use disorders, AD, alcohol dependence and those patients would be alcohol abuse or dependence either. Ns, not mention
  2. 1 Abstinence = 4 weeks of negative urine screens; 2Abstinence = the moment an individual stops using the substance