Table 3 Outcomes per measurement and estimated change from baseline

Quality of life

Patient-rated

Mean (SD)

Change from baseline per 6 months estimate, ([95%-CI])

p-value

Mean (SD)

Change from baseline per 6 months estimate, ([95%-CI])

p-value

MANSA

0.082, ([0.023,0.142])

0.007

MANSA

0.025, ([−0.050,0.101])

0.511

Baseline

4.1(0.8)

Baseline

4.8(0.8)

6 months

3.9(0.7)

6 months

4.6(1.1)

12 months

4.4(0.8)

12 months

4.6(0.8)

18 months

4.2(0.7)

18 months

4.8(0.8)

Clinician-perceived patient difficulty

Clinician-rated

DDPRQ

−0.473, ([− 0.879,-0.050])

0.029

DDPRQ

−1.297, ([−1.881,-0.713])

< 0.001

Baseline

23.8(4.8)

Baseline

22.9(4.7)

6 months

24.2(3.9)

6 months

20.6(4.9)

12 months

21.7 (4.5)

12 months

21.7(4.6)

18 months

22.3(3.7)

18 months

19.2(5.4)

PD

− 0.21, ([− 0.361,-0.074])

0.003

PD

−0.311, ([− 0.507,-0.114])

0.002

Baseline

3.3(1.3)

Baseline

3.0(1.7)

6 months

3.2(1.6)

6 months

1.8(1.1)

12 months

2.4(1.3)

12 months

2.3(1.6)

18 months

2.7(1.3)

18 months

2.3(1.2)

General Mental Health

Patient-rated

HONOS

−1.056, ([− 1.480,-0.632])

< 0.001

HONOS

− 1.180, ([− 1.763,-0.597])

< 0.001

Baseline

12.1(4.6)

Baseline

10.5(5.4)

6 months

9.7(3.9)

6 months

8.9(4.8)

12 months

8.1(4.6)

12 months

7.8(5.4)

18 months

9.1(4.9)

18 months

8.4(4.4)

Treatment

Patient-rated

OQ45

− 0.049, ([− 0.084,-0.015])

0.005

OQ45

−0.042, ([− 0.086,0.002])

0.065

Baseline

81.7(23.7)

Baseline

65.1(27.5)

6 months

83.2(22.5)

6 months

65.0(31.3)

12 months

75.4(24.8)

12 months

64.1(22.2)

18 months

72.7(24.5)

18 months

59.7(26.8)

Illness management and Recovery

Patient-rated

IMR-Patient

0.037, ([0.002,0.073])

0.036

IMR-Patient

− 0.023, ([− 0.073,0.027])

0.369

Baseline

3.2(0.4)

Baseline

3.3(0.4)

6 months

3.3(0.4)

6 months

3.3(0.4)

12 months

3.4(0,4)

12 months

3.4(0.4)

18 months

3.3(0.4)

18 months

3.3(0.3)

Clinician-rated

IMR Clinician

0.130, ([0.078,0.182])

< 0.001

IMR-Clinician

0.124, ([0.051,0.197])

0.001

Baseline

3.1(0.3)

Baseline

3.3(0.4)

6 months

3.3(0.7)

6 months

3.2(0.6)

12 months

3.5(0.3)

12 months

3.5(0.4)

18 months

3.4(0.5)

18 months

3.5(0.4)

Therapeutic relationship

Patient-rated

STAR-Patient

0.121, ([− 0.458,0.701])

0.681

STAR-Patient

− 0.499, ([−1.223,0.225])

0.176

Baseline

37.5(6.2)

Baseline

38.9(6.3)

6 months

37.2(5.9)

6 months

38.4(5.5)

12 months

38.7(5.6)

12 months

36.3(10.4)

18 months

38.2(5.1)

18 months

38.2(7.0)

Clinician-rated

STAR-Patient

0.094, ([−0.369,0.557])

0.689

STAR-Patient

0.137, ([− 0.049,0.684])

0.620

Baseline

37.5(6.2)

Baseline

39.0(3.9)

6 months

37.2(5.9)

6 months

39.7(3.2)

12 months

38.7(5.6)

12 months

39.7(4.3)

18 months

38.2(5.1)

18 months

41.3(3.9)

Care Needs

CANSAS-Patient, unmet needs

−0.260, ([− 0.413,-0.108])

< 0.001

CANSAS-Patient, unmet needs

− 0.424, ([− 0.615,-0.233])

< 0.001

Baseline

2.3(2.6)

Baseline

1.4(1.7)

6 months

1.8(2.2)

6 months

0.5(1.0)

12 months

1.4(1.9)

12 months

0.4(0.8)

18 months

1.4(2.0)

18 months

0.4(1.1)

Clinician-rated

CANSAS-Clinician unmet needs

−0.604, ([− 0.785,-0.422])

< 0.001

CANSAS-Clinician unmet needs

−0.768, ([− 0.981,-0.555])

< 0.001

Baseline

2.5(2.8)

Baseline

2.4(2.3)

6 months

1.3 (2.0)

6 months

0.5(1.2)

12 months

0.7(1.4)

12 months

0.4(1.1)

18 months

0.6(1.4)

18 months

0.2(0.7)

Social Network

Patient-rated

SNM, quality of social network

0.024, ([− 0.007,0.045])

0.128

SNM, quality of social network

0.031, ([− 0.011,0.074])

0.145

Baseline

0.6(0.5)

Baseline

0.6(0.4)

6 months

0.7(0.4)

6 months

0.8(0.4)

12 months

0.8(0.5)

12 months

0.6(0.5)

18 months

0.7(0.4)

18 months

0.7(0.4)

SNM, quantity of social network

− 0.085, ([− 0.156,-0.013])

0.020

SNM, quantity of social network

0.002, ([− 0.087,0.092])

0.960

Baseline

−0.3(1.1)

Baseline

− 0.4(0.9)

6 months

− 0.6(0.9)

6 months

− 0.4(1.3)

12 months

− 0.7(0.8)

12 months

− 0.6(0.7)

18 months

− 0.4(0.8)

18 months

− 0.4(0.9)