Fig. 4

Participant Timeline for Assessments The overall study duration will be 36 months. Trial duration, subsuming stages 1 and 2 each 12 weeks long, is 6 months (24 weeks). Recruitment will occur in months 1–24, and treatment will continue through month 30. Naturalistic follow-up will continue after the 24-week trial to assess the durability of study treatment effects and will range from 6 to 30 months, depending on when participants were recruited into the study. Months 36–43 be devoted to data analysis and draft publication of the manuscript, with submission for publication by month 50