Gender differences in the use of atypical antipsychotics in early-onset schizophrenia: a nationwide population-based study in Brazil

Table 3 Antipsychotic prescription and their mean dose for patients age 13–17 years with early-onset schizophrenia

Variables	Overall N = 31,714	Male N = 20,630	Female N = 11,084	P*
Atypical antipsychotic
Clozapine
Dose (mg/day)^&	184.45 ± 338.72	178.88 ± 166.22	195.43 ± 535.82	0.490
Mean dose/DDD ratio	0.61 ± 1.12	0.59 ± 0.55	0.65 ± 1.78
Olanzapine
Dose (mg/day)^&	5.42 ± 8.57	5.60 ± 9.85	5.09 ± 5.35	0.012
Mean dose /DDD ratio	0.54 ± 0.85	0.56 ± 0.98	0.51 ± 0.53
Risperidone
Dose (mg/day)^&	1.42 ± 2.66	1.44 ± 2.40	1.37 ± 3.18	0.093
Mean dose /DDD ratio	0.28 ± 0.53	0.29 ± 0.48	0.27 ± 0.63
Quetiapine
Dose (mg/day)^&	107.78 ± 247.59	114.87 ± 327.43	100.28 ± 112.41	0.041
Mean dose /DDD ratio	0.26 ± 0.62	0.28 ± 0.82	0.25 ± 0.28
Ziprasidone
Dose (mg/day)^&	61.10 ± 131.82	65.41 ± 148.99	56.22 ± 109.02	0.220
Mean dose /DDD ratio	0.76 ± 1.64	0.81 ± 1.86	0.70 ± 1.36

^& t-test was performed to compare mean dose (mg/day) between male and female; * p-value refers to the difference between male and female

ISSN: 1471-244X