Fig. 1

Top section - Axial and sagittal slices of the patient’s brain acquired on a PET/MRI; T1-weighted anatomical (left), FDG-PET (middle) and FDG-PET overlaid onto T1-weighted (right). No significant brain atrophy was detected on volumetric measurement of T1-weighted images. Decreased FDGuptake was visible in the frontal and temporal regions of the brain. Bottom section - FDG-PET t-map (t > 2, p < 0.05) overlaid to the standard MNI T1-weighted image. Areas of hypometabolism (blue-green) were observed in medial superior frontal, insula, inferior temporal, thalamus, and anterior cingulate cortex