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Table 6 Cornell Scale for Depression in Dementia predicted by week, condition, dementia severity and baseline total using multilevel regression

From: The effects of bright light treatment on affective symptoms in people with dementia: a 24-week cluster randomized controlled trial

Predictors

Total

Mood-related signs

Behavioral disturbance

Cyclic functions

Estimates (CI)

Std. betas (SD)

Estimates (CI)

Std. betas (SD)

Estimates (CI)

Std. betas (SD)

Estimates (CI)

Std. betas (SD)

Week (8)

1.6 (− 0.3–3.5)

0.3 (1.6)

0.6 (− 0.1–1.2)

0.3 (1.8)

0.5 (− 0.2–1.1)

0.3 (1.3)

0.4 (− 0.3–1.0)

0.2 (1.1)

Week (16)

-0.8 (−2.8–1.3)

-0.1 (− 0.7)

0.3 (− 0.3–1.0)

0.2 (1.0)

− 0.6 (− 1.3–0.1)

− 0.4 (− 1.7)

− 0.6 (− 1.3–0.1)

− 0.3 (− 1.6)

Week (24)

− 1.2 (−3.2–0.8)

− 0.2 (− 1.2)

0.1 (− 0.5–0.8)

0.1 (0.5)

−0.4 (− 1.1–0.3)

−0.2 (− 1.1)

−0.6 (− 1.3–0.1)

−0.3 (− 1.7)

Condition [Intervention]

2.1 (− 0.1–4.2)

0.4 (1.9)

0.6 (− 0.1–1.3)

0.3 (1.6)

0.4 (− 0.3–1.1)

0.2 (1.1)

0.5 (−0.1–1.2)

0.3 (1.6)

Interactions (indicating treatment effect)

 

 Week (8) * [Intervention]

−2.7 (−5.4–0.0)

−0.5 (− 1.9)

− 1.0 *(− 1.9 – − 0.1)

− 0.5 (− 2.3)

−0.4 (− 1.4–0.5)

−0.2 (− 0.9)

−0.6 (− 1.5–0.3)

−0.3 (− 1.3)

 Week (16) * [Intervention]

− 3.2 *(−6.0 – − 0.3)

− 0.6 (− 2.2)

−1.8 ***(− 2.7 – − 0.8)

−0.9 (− 3.8)

−0.0 (− 1.0–0.9)

−0.0 (− 0.1)

−0.1 (− 1.1–0.8)

−0.1 (− 0.3)

 Week (24) * [Intervention]

−1.0 (− 3.8–1.8)

−0.2 (− 0.7)

−0.8 (− 1.6–0.1)

−0.4 (− 1.7)

0.4 (− 0.5–1.4)

0.3 (0.9)

−0.5 (− 1.5–0.4)

−0.3 (− 1.1)

Covariates

 

 FAST

0.2 (−0.9–1.2)

0.0 (0.3)

−0.3 (− 0.6–0.1)

−0.1 (− 1.5)

0.1 (− 0.3–0.4)

0.0 (0.3)

0.2 (− 0.1–0.6)

0.1 (1.4)

 Baseline DV

0.6 ***(0.4–0.7)

0.6 (8.6)

0.6 ***(0.5–0.8)

0.7 (8.8)

0.5 ***(0.4–0.6)

0.5 (7.4)

0.5 ***(0.4–0.6)

0.6 (9.6)

Model information

 

 ICC (id)

0.25

0.32

0.18

0.11

 Marginal R2 / Conditional R2

0.423 / 0.567

0.436 / 0.614

0.334 / 0.454

0.415 / 0.480

  1. * p < 0.05, ** p < 0.01, *** p < 0.001. In italics: significant after Benjamini-Hochberg correction for false discovery rate with all eight models. Std. betas standardized regression coefficients, SD standard deviation, CI 95% confidence interval, SD standard deviation, FAST Functional Assessment Staging Test, DV dependent variable, ICC intraclass correlation coefficient