Alteration in the mRNA expression profile of the autophagy-related mTOR pathway in schizophrenia patients treated with olanzapine

Table 3 Comparison of mTOR pathway genes expression levels in three groups

	Case group		Control group	F	p	Multiple comparisons
	Baseline (n = 45)	After treatment (n = 32)	(n = 46)	F	p	MD^a	MD^b	MD^c
MTOR^a,b,c	1.08 ± 0.59	0.51 ± 0.30	2.41 ± 1.19	57.03	0.000	0.568	1.338	1.906
DEPTOR^a,c	1.00 ± 0.61	4.92 ± 1.75	0.75 ± 0.52	188.445	0.000	3.913	0.251	4.164
RAPTOR ^c	1.79 ± 1.07	1.60 ± 1.13	2.27 ± 1.28	3.70	0.028	0.191	0.492	0.683
RICTOR^a,b,c	1.06 ± 0.58	0.49 ± 0.29	3.18 ± 1.48	86.80	0.000	0.564	2.128	2.692

Note: Levene variance homogeneity test showed that the expression level data of four target genes were not uniform. One way ANOVA was used to compare the expression levels of target genes in 3 groups, and Tamhane’s T2 test was used to multiple comparisons
^a Comparison of mRNA expression levels of target genes in case group before and after treatment had significant difference (p < 0.05);
^b Comparison of mRNA expression levels of target genes between control group and case group before treatment had significant difference (p < 0.05);
^c Comparison of mRNA expression levels of target genes between control group and case group after treatment had significant difference (p < 0.05)

ISSN: 1471-244X