Table 1 Endorsement of specific symptoms of DSM criteria for major depression, melancholia, and atypical specifiers in patients with MDD, MDD with melancholic features, and MDD with atypical features, as determined by the IDS in STAR*D (N=2496)

Sad mood

93.43

2332

94.21

992

90.00

243

Lost interest

79.41

1982

82.34

867

70.00

189

Lost pleasure^a

60.34

1506

79.68

839

35.56

96

Appetite/weight decrease^a

45.15

1127

64.20

676

21.11

57

Appetite/weight increase^b

27.24

680

19.66

207

57.78

156

Insomnia

91.11

2274

95.44

1005

86.67

234

Hypersomnia^b

14.82

370

11.49

121

32.96

89

Psychomotor retardation^a

9.26

231

14.82

156

6.67

18

Psychomotor agitation^a

30.45

760

47.20

497

20.37

55

Fatigue

80.50

2009

79.68

839

82.96

224

Worthlessness/guilt^a

76.60

1912

86.71

913

75.56

204

Diminished concentration

87.98

2196

88.70

934

87.04

235

Suicidality

19.79

494

25.55

269

12.59

34

Unreactive mood

57.53

1436

76.73

808

0.00

0

Distinct quality of mood

49.68

1240

64.77

682

47.78

129

Depression worse AM^c

10.86

271

17.28

182

6.30

17

Early morning awakening

49.80

1243

72.27

761

34.07

92

Mood reactivity

42.47

1060

23.27

245

100.00

270

Leaden paralysis

32.29

806

33.24

350

59.26

160

Rejection sensitivity

51.88

1295

57.45

605

78.52

212